Central cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats

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dc.creatorSueli Ferreira da Fonseca
dc.creatorVanessa Amaral Mendonça
dc.creatorSara Barros Silva
dc.creatorTalita Emanuela Domingues
dc.creatorDirceu Sousa Melo
dc.creatorJeanne Brenda Martins
dc.creatorWashington Pires
dc.creatorCynthia Ferreira Fernandes Santos
dc.creatorWagner de Fátima Pereira
dc.creatorLaura Hora Rios Leite
dc.creatorCândido Celso Coimbra
dc.creatorHércules Ribeiro Leite
dc.creatorAna Cristina Rodrigues Lacerda
dc.date.accessioned2022-11-04T17:36:18Z
dc.date.accessioned2025-09-08T23:51:34Z
dc.date.available2022-11-04T17:36:18Z
dc.date.issued2018-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.jtherbio.2018.08.014
dc.identifier.issn1879-0992
dc.identifier.urihttps://hdl.handle.net/1843/46929
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Thermal Biology
dc.rightsAcesso Restrito
dc.subjectCorpo - Temperatura - Regulação
dc.subjectFisostigmina
dc.subjectHipertensão
dc.subjectSinapses
dc.subject.otherThermoregulation
dc.subject.otherPhysostigmine
dc.subject.otherHypertension
dc.subject.otherCentral cholinergic synapses
dc.titleCentral cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats
dc.typeArtigo de periódico
local.citation.epage95
local.citation.spage86
local.citation.volume77
local.description.resumoThere is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 µL of physostigmine (phy) or saline solution. Tail temperature (Ttail), internal body temperature (Tint), systolic arterial pressure (SAP), heart rate (HR) and metabolic rate were registered during 60 min while the animals remained at rest after randomly receiving the injections. The variability of the SAP and the HR was estimated by the fast Fourier transform. Phy treatment began a succession of cardiovascular and thermoregulatory responses that resulted in increased SAP, reduced HR and increased Ttail in both Wistar and SHRs groups. The magnitude of these effects seems to be more intense in SHRs, since the improvement of heat dissipation reflected in Tint. Taken together, these results provide evidence that hypertensive rats present greater cardiovascular and thermoregulatory responses than normotensive rats after central cholinergic stimulation.
local.identifier.orcidhttps://orcid.org/0000-0001-8020-8511
local.identifier.orcidhttps://orcid.org/0000-0002-1696-6091
local.identifier.orcidhttps://orcid.org/0000-0002-7593-7514
local.identifier.orcidhttps://orcid.org/0000-0002-8708-3245
local.identifier.orcidhttps://orcid.org/0000-0003-4982-4388
local.identifier.orcidhttps://orcid.org/0000-0001-8981-6724
local.identifier.orcidhttp://orcid.org/0000-0001-8977-8131
local.identifier.orcidhttps://orcid.org/0000-0001-5366-3754
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0306456518300986?via%3Dihub#!

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