Why did ZIKV Perinatal outcomes differ in distinct regions of Brazil? An exploratory study of two cohorts

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dc.creatorLuana Damasceno
dc.creatorAna Carolina Bernardes Terzian
dc.creatorTrevon Fuller
dc.creatorCassia Estofolete
dc.creatorAdriana Andrade
dc.creatorErna Geessien Kroon
dc.creatorAndrea Zin
dc.creatorZilton Vasconcelos
dc.creatorJosé Pereira Júnior
dc.creatorMárcia Castilho
dc.creatorIsa Cristina Ribeiro Piauilino
dc.creatorNikos Vasilakis
dc.creatorMaria Moreira
dc.creatorKarin Nielsen-Saines
dc.creatorFlor Martinez Espinosa
dc.creatorMauricio Lacerda Nogueira
dc.creatorPatricia Brasil
dc.date.accessioned2025-02-11T21:16:52Z
dc.date.accessioned2025-09-08T23:57:53Z
dc.date.available2025-02-11T21:16:52Z
dc.date.issued2021-04-23
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/v13050736
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/1843/79930
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofViruses
dc.rightsAcesso Aberto
dc.subjectGravidez
dc.subjectInfecção por Zika virus
dc.subjectPerinatologia
dc.subjectArbovírus
dc.subject.otherZika
dc.subject.otherPregnancy
dc.subject.otherObstetrics
dc.subject.otherArboviruses
dc.subject.otherDengue
dc.titleWhy did ZIKV Perinatal outcomes differ in distinct regions of Brazil? An exploratory study of two cohorts
dc.typeArtigo de periódico
local.citation.epage12
local.citation.issue5
local.citation.spage1
local.citation.volume13
local.description.resumoThe Zika virus (ZIKV) epidemic in Brazil occurred in regions where dengue viruses (DENV) are historically endemic. We investigated the differences in adverse pregnancy/infant outcomes in two cohorts comprising 114 pregnant women with PCR-confirmed ZIKV infection in Rio de Janeiro, Southeastern Brazil (n = 50) and Manaus, in the north region of the country (n = 64). Prior exposure to DENV was evaluated through plaque reduction neutralizing antibody assays (PRNT 80) and DENV IgG serologies. Potential associations between pregnancy outcomes and Zika attack rates in the two cities were explored. Overall, 31 women (27%) had adverse pregnancy/infant outcomes, 27 in Rio (54%) and 4 in Manaus (6%), p < 0.001. This included 4 pregnancy losses (13%) and 27 infants with abnormalities at birth (24%). A total of 93 women (82%) had evidence of prior DENV exposure, 45 in Rio (90%) and 48 in Manaus (75%). Zika attack rates differed; the rate in Rio was 10.28 cases/10,000 and in Manaus, 0.6 cases/10,000, p < 0.001. Only Zika attack rates (Odds Ratio: 17.6, 95% Confidence Interval 5.6–55.9, p < 0.001) and infection in the first trimester of pregnancy (OR: 4.26, 95% CI 1.4–12.9, p = 0.011) were associated with adverse pregnancy and infant outcomes. Pre-existing immunity to DENV was not associated with outcomes (normal or abnormal) in patients with ZIKV infection during pregnancy.
local.identifier.orcidhttps://orcid.org/0000-0001-7157-7825
local.identifier.orcidhttps://orcid.org/0000-0001-9954-4267
local.identifier.orcidhttps://orcid.org/0000-0001-7324-1591
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0001-7677-0034
local.identifier.orcidhttps://orcid.org/0000-0002-2193-2224
local.identifier.orcidhttps://orcid.org/0000-0003-3327-6778
local.identifier.orcidhttps://orcid.org/0000-0002-0708-3289
local.identifier.orcidhttps://orcid.org/0000-0002-2034-0294
local.identifier.orcidhttps://orcid.org/0000-0002-1742-5211
local.identifier.orcidhttps://orcid.org/0000-0003-1102-2419
local.identifier.orcidhttps://orcid.org/0000-0001-9555-7976
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1999-4915/13/5/736

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