Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions

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dc.creatorFernando Marcos Dos Reis
dc.creatorAdelina M. Reis
dc.date.accessioned2023-10-05T23:04:17Z
dc.date.accessioned2025-09-09T00:03:30Z
dc.date.available2023-10-05T23:04:17Z
dc.date.issued2020
dc.identifier.doihttps://doi.org/10.1042/CS20200865
dc.identifier.issn1470-8736
dc.identifier.urihttps://hdl.handle.net/1843/59242
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Science
dc.rightsAcesso Restrito
dc.subjectPlacenta
dc.subjectEndometrio
dc.subjectOvarios
dc.subject.otherAngiotensin 1-7
dc.subject.otherMAS
dc.subject.otherACE2
dc.subject.otherOvary
dc.subject.otherEndometrium
dc.subject.otherPlacenta
dc.titleAngiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions
dc.typeArtigo de periódico
local.citation.epage2941
local.citation.issue22
local.citation.spage2929
local.citation.volume134
local.description.resumoAngiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other peptidases, or by a single cleavage of Ang II catalyzed chiefly by ACE2. The effects of Ang-(1-7) are mediated by the G protein-coupled receptor Mas (or Mas1), encoded by the protooncogene MAS. The reproductive system expresses ACE2 quite abundantly and therefore is able to generate Ang-(1-7) using precursor peptides produced locally or taken from circulation. In several mammalian species, Ang-(1-7) stimulates ovarian follicle growth, oocyte maturation and ovulation. The peptide is found in human endometrium, mostly during the secretory phase of menstrual cycle when the uterus is receptive to embryo implantation. Rat models and human observational studies suggest that Ang-(1-7) is part of the maternal adaptive response to pregnancy and its deficiency is associated withpoor circulation in the placental bed.KnockoutmicerevealedarelevantparticipationofMas-mediatedstimulustothemaintenanceofnormalspermatogenesis,eventhoughtheanimalcanstillreproducewithoutit.In addition, thevasorelaxant effect ofAng-(1-7) participates inthephysiological mechanism of corpus cavernosum blood influx and penile erection. We conclude that preclinical evidence encourages the pursuit of treatments for female and male reproductive dysfunctions based on Mas agonists, starting with its natural ligand Ang-(1-7).
local.identifier.orcidhttps://orcid.org/0000-0003-0138-9612
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://portlandpress.com/clinsci/article/134/22/2929/226965/Angiotensin-converting-enzyme-2-ACE2-angiotensin-1

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