Liver damage produced by malnutrition is improved by dietary supplementation in mice: assessment of a supplement based on buriti (a cerrado fruit) and dairy by-products

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dc.creatorAudrey Handyara Bicalho
dc.creatorFabio Ribeiro dos Santos
dc.creatorDaniele Cristina Moreira
dc.creatorLuís Paulo Oliveira
dc.creatorAmanda Souto Machado
dc.creatorLucyana Conceição Farias
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2023-04-26T12:35:00Z
dc.date.accessioned2025-09-08T23:06:34Z
dc.date.available2023-04-26T12:35:00Z
dc.date.issued2021-01-01
dc.identifier.doi10.2174/2212798411999210101224626
dc.identifier.issn1876-1429
dc.identifier.urihttps://hdl.handle.net/1843/52497
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRecent Patents on Food, Nutrition & Agriculture
dc.rightsAcesso Restrito
dc.subjectDesnutrição
dc.subjectSuplementos dietéticos
dc.subjectFígado - Doenças
dc.subjectEstresse oxidativo
dc.subjectBuriti
dc.titleLiver damage produced by malnutrition is improved by dietary supplementation in mice: assessment of a supplement based on buriti (a cerrado fruit) and dairy by-products
dc.typeArtigo de periódico
local.citation.epage35
local.citation.issue1
local.citation.spage29
local.citation.volume12
local.description.resumoBackground: malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates an inflammatory state and increases oxidative stress. The liver is one of the body vital organs, becoming necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition. Aims: to evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated genes, as well as biochemical and histological parameters. Methods: swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed with different diets. Results: our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market. Conclusion: our work presents a new composition of low cost food supplement based on buriti and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/112970

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