Clinical correlation of transcription factor SOX3 in cancer: unveiling its role in tumorigenesis

Página do item simplificado
dc.creatorHelen Lima Del Puerto
dc.creatorAna Paula Gomes dos Santos Miranda
dc.creatorDinah Qutob
dc.creatorEnio Ferreira
dc.creatorFelipe Henrique de Souza Silva
dc.creatorBruna Lima
dc.creatorBarbara Carvalho
dc.creatorBruna Roque-Souza
dc.creatorEduardo Gutseit
dc.creatorDiego Castro
dc.creatorEmanuele Pozzolini
dc.creatorNayara Duarte
dc.creatorThacyana Lopes
dc.creatorDaiana Taborda
dc.creatorStella Quirino
dc.creatorAhmed Elgerbi
dc.creatorJohn Choy
dc.creatorAdam Underwood
dc.date.accessioned2026-01-06T20:58:39Z
dc.date.issued2024-06-13
dc.identifier.doihttps://doi.org/10.3390/genes15060777
dc.identifier.issn2073-4425
dc.identifier.urihttps://hdl.handle.net/1843/1295
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGenes
dc.rightsAcesso aberto
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCarcinogênese
dc.subjectTransição Epitelial-Mesenquimal
dc.subject.otherSOX3
dc.subject.otherCancer
dc.subject.otherInvasion;
dc.subject.otherMigration
dc.subject.otherCell cycle
dc.subject.otherCancer
dc.subject.otherCell cycle
dc.subject.otherProliferation
dc.titleClinical correlation of transcription factor SOX3 in cancer: unveiling its role in tumorigenesis
dc.typeArtigo de periódico
local.citation.epage22
local.citation.issue6
local.citation.spage1
local.citation.volume15
local.description.resumoMembers of the SOX (SRY-related HMG box) family of transcription factors are crucial for embryonic development and cell fate determination. This review investigates the role of SOX3 in cancer, as aberrations in SOX3 expression have been implicated in several cancers, including osteosarcoma, breast, esophageal, endometrial, ovarian, gastric, hepatocellular carcinomas, glioblastoma, and leukemia. These dysregulations modulate key cancer outcomes such as apoptosis, epithelialmesenchymal transition (EMT), invasion, migration, cell cycle, and proliferation, contributing to cancer development. SOX3 exhibits varied expression patterns correlated with clinicopathological parameters in diverse tumor types. This review aims to elucidate the nuanced role of SOX3 in tumorigenesis, correlating its expression with clinical and pathological characteristics in cancer patients and cellular modelsBy providing a comprehensive exploration of SOX3 involvement in cancer, this review underscores the multifaceted role of SOX3 across distinct tumor types. The complexity uncovered in SOX3 function emphasizes the need for further research to unravel its full potential in cancer therapeutics.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA::ANATOMIA PATOLOGICA E PATOLOGIA CLINICA
local.url.externahttps://www.mdpi.com/2073-4425/15/6/777

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Clinical correlation of transcription factor SOX3 in cancer: unveiling its role in tumorigenesis.pdf
Tamanho:
1.15 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
license.txt
Tamanho:
2.07 KB
Formato:
Item-specific license agreed to upon submission
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG