Eosinophil-Associated Innate IL-17 response promotes Aspergillus fumigatus Lung Pathology

Página do item simplificado
dc.creatorNathália Luísa Sousa de Oliveira Malacco
dc.creatorFrederico Marianetti Soriani
dc.creatorMilene Alvarenga Rachid
dc.creatorIsabella Luisa da Silva Gurgel
dc.creatorTauany Rodrigues Moura
dc.creatorPedro Henrique Ferreira Sucupira
dc.creatorLirlândia Pires de Sousa
dc.creatorDaniele da Glória de Souza
dc.creatorRemo de Castro Russo
dc.creatorMauro Martins Teixeira
dc.date.accessioned2023-07-14T22:48:55Z
dc.date.accessioned2025-09-09T01:04:30Z
dc.date.available2023-07-14T22:48:55Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.3389/fcimb.2018.00453
dc.identifier.issn2235-2988
dc.identifier.urihttps://hdl.handle.net/1843/56335
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Cellular and Infection Microbiology
dc.rightsAcesso Aberto
dc.subjectEosinofilos
dc.subjectInfecção
dc.subjectImunidade
dc.subject.otherEosinophils role in inflammation
dc.subject.otherFungal infection
dc.subject.otherInnate immunity
dc.subject.otherIL-17 innate response
dc.subject.otherEosinophil lung damage
dc.titleEosinophil-Associated Innate IL-17 response promotes Aspergillus fumigatus Lung Pathology
dc.typeArtigo de periódico
local.citation.epage13
local.citation.spage1
local.citation.volume8
local.description.resumoAspergillus fumigatus is a common widespread microorganism with environmental, biological and clinical relevance. After inhalation, swollen conidia can germinate, colonize and invade pulmonary tissues. Eosinophils have been described as key cells in A. fumigatus lung infection. However, their specific role in protecting or damaging lung tissue as well as their relatioship among different A. fumigatus strains is poorly understood. Previously, it has been reported that eosinophils are able to produce IL17 and mediate an innate response that protected mice from infection using Af293 and CEA10 strains. Here, we have developed a set of new experiments with the CEA17-derived A1163 strain of A. fumigatus. Using 1dblGATA1 mice, we demonstrate that eosinophils produce IL-17 and are involved in control of neutrophil, macrophage and lymphocyte recruitment. We found that eosinophils also induce high levels of cytokines and chemokines, generating an intense inflammatory process. Eosinophils are responsible for increased pulmonary dysfunction and elevated lethality rates in mice. Curiously, fungal burden was not affected. To address the role of IL-17 signaling, pharmacological inhibition of this mediator in the airways with anti-IL-17 antibody was able to reduce inflammation in the airways and protect infected mice. In conclusion, our results demonstrate that eosinophils control IL-17-mediated response and contribute to lung pathology after A. fumigatus infection. Therefore, eosinophils may represent a potential target for controlling exacerbated inflammation and prevent tissue damage during this fungal infection.
local.identifier.orcidhttps://orcid.org/0000-0002-5823-2184
local.identifier.orcidhttps://orcid.org/0000-0003-4720-6746
local.identifier.orcidhttps://orcid.org/0000-0002-3142-6552
local.identifier.orcidhttps://orcid.org/0000-0002-1797-6080
local.identifier.orcidhttps://orcid.org/0000-0003-2778-7221
local.identifier.orcidhttps://orcid.org/0000-0002-1997-1590
local.identifier.orcidhttps://orcid.org/0000-0002-1042-9762
local.identifier.orcidhttps://orcid.org/0000-0002-1715-3834
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fcimb.2018.00453/full

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Eosinophil-Associated Innate IL-17 Response Promotes Aspergillus fumigatus Lung Pathology.pdf
Tamanho:
46.18 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG