Serum levels of vancomycin: is there a prediction using doses in mg/kg/day or m2/day for neonates?

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dc.creatorRoberta Maia de Castroromanelli
dc.creatorLeni Márcia Anchieta
dc.creatorJuliana Chaves Abreu Fernandes
dc.creatorMariana Antunes Faria Lima
dc.creatorTaís Marina de Souza
dc.creatorViviane Rosado
dc.creatorWanessa Trindade Clemente
dc.creatorPaulo Augusto Moreira Camargos
dc.date.accessioned2023-06-30T19:29:48Z
dc.date.accessioned2025-09-08T23:15:37Z
dc.date.available2023-06-30T19:29:48Z
dc.date.issued2016-08-12
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.bjid.2016.06.008
dc.identifier.issn14138670
dc.identifier.urihttps://hdl.handle.net/1843/55647
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subjectVancomicina
dc.subjectCálculos da Dosagem de Medicamento
dc.subjectFarmacocinética
dc.subjectLactente
dc.subjectRecém-Nascido
dc.subjectSepse Neonatal
dc.subject.otherVancomycin
dc.subject.otherDrug dosage calculations
dc.subject.otherPharmacokinetics
dc.subject.otherInfant
dc.subject.otherNewborn
dc.subject.otherSepsis
dc.titleSerum levels of vancomycin: is there a prediction using doses in mg/kg/day or m2/day for neonates?
dc.typeArtigo de periódico
local.citation.epage456
local.citation.spage451
local.citation.volume20
local.description.resumoCoagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m2/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013. Newborns treated with vancomycin for the first episode of late-onset sepsis were included. Total dose in mg/kg/day, dose/m2/day, age, weight, body surface and gestational age were identified as independent variables. For predictive analysis of adequate serum levels, multiple linear regressions were performed. The Receiver Operating Characteristic curve for proper serum vancomycin levels was also obtained. A total of 98 patients received 169 serum dosages of the drug, 41 (24.3%) of the doses had serum levels that were defined as appropriate. Doses prescribed in mg/kg/day and dose/m2/day predicted serum levels in only 9% and 4% of cases, respectively. Statistical significance was observed with higher doses when the serum levels were considered as appropriate (p < 0.001). A dose of 27 mg/kg/day had a sensitivity of 82.9% to achieve correct serum levels of vancomycin. Although vancomycin has erratic serum levels and empirical doses cannot properly predict the target levels, highest doses in mg/kg/day were associated with adequate serum levels
local.identifier.orcidhttps://orcid.org/0000-0003-0848-3740
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bjid/a/nD6MvFqZ7JBSdVfxLYGX5Vv/?lang=en

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