Hyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial

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dc.creatorCarlos Eduardo Pinto de Alcântara
dc.creatorMaurício Augusto Aquino de Castro
dc.creatorMariana Saturnino de Noronha
dc.creatorPaulo Antônio Martins-Junior
dc.creatorRenato de Melo Mendes
dc.creatorMarcelo Vidigal Caliari
dc.creatorRicardo Alves de Mesquita
dc.creatorAnderson José Ferreira
dc.date.accessioned2025-07-03T20:27:01Z
dc.date.accessioned2025-09-08T22:54:59Z
dc.date.available2025-07-03T20:27:01Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2018.vol32.0084
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/83321
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectHyaluronic acid
dc.subjectTooth socket
dc.subjectCone-beam computed tomography
dc.subjectOsteogenesis
dc.subjectFractals
dc.subjectEvaluation study
dc.subject.otherHyaluronic acid
dc.subject.otherTooth socket
dc.subject.otherCone beam computed tomography
dc.titleHyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume32
local.description.resumoThis study evaluated the effects of hyaluronic acid (HA) on bone repair of human dental sockets. Thirty-two lower first premolars were extracted from 16 patients (2 per patient) for orthodontic reasons. Following the extractions, one socket was randomly filled with 1% HA gel, while the other was allowed to naturally fill with blood clot. After 30 and 90 days of surgery, patients underwent cone beam computed tomography. Five central orthoradial slices were captured from each socket. The gray intensity was measured in each image and results were reported as mean percentage of bone formation. The buccolingual alveolar ridge width was measured and dimensional changes were compared between the postoperative intervals. The pattern of alveolar trabecular bone was evaluated through the fractal dimension. Treated sockets showed a higher percentage of bone formation and fractal dimension values (58.17% and 1.098, respectively) compared with controls (48.97% and 1.074, respectively) in the 30-day postoperative period (p < 0.05). After 90 days, there was no significant difference between groups. Additionally, no significant difference was found between groups regarding the alveolar dimensions (p > 0.05). Use of 1% HA gel after tooth extraction accelerates bone repair in human dental sockets.
local.identifier.orcidhttps://orcid.org/0000-0001-6013-9344
local.identifier.orcidhttps://orcid.org/0000-0001-9188-1939
local.identifier.orcidhttps://orcid.org/0000-0002-1575-5364
local.identifier.orcidhttps://orcid.org/0000-0001-8354-8407
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/CRGVc8ksQGW5zdHpCYhHkRB/?lang=en

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