Genetic variation in the promoter region of the TNF rs1800629 gene is not associated with adiposity index, but AA genotype is more likely to have low cellular membrane integrity

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dc.creatorRosângela Ramos Veloso Silva
dc.creatorMarise Fagundes Silveira
dc.creatorGeórgia das Graças Pena
dc.creatorTatiana Carvalho Reis Martins
dc.creatorUgo Borges Pinheiro
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorJoão Felício Rodrigues Neto
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-24T15:06:31Z
dc.date.accessioned2025-09-08T22:48:42Z
dc.date.available2022-08-24T15:06:31Z
dc.date.issued2017-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.mgene.2017.05.005
dc.identifier.issn2214-5400
dc.identifier.urihttps://hdl.handle.net/1843/44525
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMeta Gene
dc.rightsAcesso Aberto
dc.subjectObesidade
dc.subjectPolimorfismo (Genética)
dc.subjectFator de necrose de tumor
dc.subjectAntropometria
dc.subjectTecido adiposo
dc.titleGenetic variation in the promoter region of the TNF rs1800629 gene is not associated with adiposity index, but AA genotype is more likely to have low cellular membrane integrity
dc.typeArtigo de periódico
local.citation.epage91
local.citation.spage85
local.citation.volume13
local.description.resumoBackground: the complex pathophysiology of obesity includes low-grade chronic inflammation of white adipose tissue, an increase in plasma levels of pro-inflammatory cytokines as well as genetic factors, which have all emerged as important risk factors. Objective: evaluate the association between the TNFα-308G/A variant and sociodemographic, clinical and behavioral variables in an urban population using overall and central obesity as the measured outcome. Methods: a cross-sectional population-based study was conducted. Anthropometric measures and genotyping were assessed in 808 individuals. The associations were tested using the hierarchical theoretical model and multiple logistic regressions. Results: thirty-one percent of subjects were overweight while 19.4% were obese. No association was observed between genotype frequencies of TNFα-308G/A and either obesity or other variables of adiposity, including waist circumference, waist to height ratio, conicity index, and fat mass. However, age, gender, physical inactivity, and other comorbidities were associated with measures of excess adiposity in the hierarchical model. The phase angle of AA genotype was lower than GA and GG genotypes (p < 0.05). Conclusion: the rs1800629 SNP of the TNFA gene was not associated with the adiposity indicators evaluated in this based population study. However, AA genotype is more likely to have low cellular membrane integrity.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2214540017300373

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