The long-term impact of high levels of alpha-melanocyte-stimulating hormone in energy balance among obese adolescents

Página do item simplificado
dc.creatorAna Claudia Pelissari Kravchychyn
dc.creatorRaquel Munhoz da Silveira Campos
dc.creatorFlávia Campos Corgosinho
dc.creatorDeborah Cristina Landi Masquio
dc.creatorSofia Emanuelle de Castro Ferreira Vicente
dc.creatorRaquel munhoz da silveira Campos
dc.creatorFlávia campos Corgosinho
dc.creatorDeborah cristina landi Masquio
dc.creatorSofia Emanuelle de Castro Ferreira Vicente
dc.creatorYasmin Alaby Martins Ferreira
dc.creatorPatrícia Leão da Silva Agostinho
dc.creatorAline de Piano Ganen
dc.creatorLila Missae Oyama
dc.creatorLian Tock
dc.creatorMarco Túlio de Mello
dc.creatorSérgio Tufik
dc.creatorAna Raimunda Dâmaso
dc.date.accessioned2023-03-31T14:29:29Z
dc.date.accessioned2025-09-08T23:48:02Z
dc.date.available2023-03-31T14:29:29Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.identifier.doihttps://doi.org/10.1159/issn.0250-6807
dc.identifier.issn1421-9697
dc.identifier.urihttps://hdl.handle.net/1843/51432
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnnals of Nutrition and Metabolism
dc.rightsAcesso Restrito
dc.subjectMetabolismo energético
dc.subjectObesidade
dc.subjectAdolescentes
dc.subject.otherEnergy balance
dc.subject.otherObesity
dc.subject.otherAdolescents
dc.titleThe long-term impact of high levels of alpha-melanocyte-stimulating hormone in energy balance among obese adolescents
dc.typeArtigo de periódico
local.citation.epage286
local.citation.issue4
local.citation.spage279
local.citation.volume72
local.description.resumoBackground: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents. Methods: One hundred ten post-pubertal obese adolescents (body mass index >95th percentile) were submitted to 1 year of interdisciplinary therapy (clinical, nutritional, psychological, physical exercise, and physiotherapy support). Body composition and plasma levels of α-MSH, neuropeptide Y (NPY), melanin-concentrating hormone, and agouti-related peptide (AgRP) were measured before and after therapy. The volunteers were grouped on the basis of Tertiles of α-MSH concentration: Low (<0.75 ng/mL), Medium (≤0.76 to ≥1.57 ng/mL), and High (>1.57 ng/mL). Significance was set as p < 0.05. Results: The treatment promoted a significant improvement in body adiposity and fat free mass for all groups. It is important to note that only in the high α-MSH group, a significant increase of the α-MSH/NPY ratio and decrease NPY/AgRP ratio post treatment were observed. Conclusion: The high α-MSH concentration promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents following long-term weight loss therapy and this is important in clinical practice.
local.identifier.orcidhttps://orcid.org/0000-0002-2919-2806
local.identifier.orcidhttps://orcid.org/0000-0001-6132-4349
local.identifier.orcidhttps://orcid.org/0000-0002-8684-7290
local.identifier.orcidhttps://orcid.org/0000-0003-0187-6402
local.identifier.orcidhttps://orcid.org/0000-0002-6913-7879
local.identifier.orcidhttps://orcid.org/0000-0002-6913-7879
local.identifier.orcidhttps://orcid.org/0000-0001-5705-6767
local.identifier.orcidhttps://orcid.org/0000-0003-4025-6257
local.identifier.orcidhttps://orcid.org/0000-0001-6433-0816
local.identifier.orcidhttps://orcid.org/0000-0002-7078-6526
local.identifier.orcidhttps://orcid.org/0000-0003-0834-904X
local.identifier.orcidhttps://orcid.org/0000-0003-3896-2208
local.identifier.orcidhttps://orcid.org/0000-0002-4012-4951
local.identifier.orcidhttps://orcid.org/0000-0001-7675-7470
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://www.karger.com/Journal/Details/223977

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG