In-depth characterization of congenital Zika syndrome in immunocompetent mice: antibody-dependent enhancement and an antiviral peptide therapy

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dc.creatorVidyleison N. camargos
dc.creatorVictória F. Queiroz
dc.creatorAna Carolina F. Dias
dc.creatorKarina T. O. Santana
dc.creatorIngredy Passos
dc.creatorAna Luíza C. V. Real
dc.creatorLudmila C. Silva
dc.creatorFlávio A. G. Mourão
dc.creatorNatália T. Wnuk
dc.creatorMilton A. P. Oliveira
dc.creatorSoraia Macari
dc.creatorGiselle Foureaux
dc.creatorTarcília Silva
dc.creatorGustavo P. Garlet
dc.creatorJoshua A. Jackman
dc.creatorFrederico M. Soriani
dc.creatorMárcio F. D. Moraes
dc.creatorEduardo M. A. M. Mendes
dc.creatorFabíola M. Ribeiro
dc.creatorGuilherme M. J. Costa
dc.creatorAntônio L. Teixeira
dc.creatorNam-Joon Cho
dc.creatorDaniel C. Medeiros
dc.creatorAntônio C. P. Oliveira
dc.creatorMauro Martins Teixeira
dc.creatorVivian V. Costa
dc.creatorDanielle G. Souza
dc.creatorVivian T. da Silveira
dc.creatorCelso M. Queiroz-Junior
dc.creatorAna Luisa B. Matosinhos
dc.creatorAndré F. A. Figueiredo
dc.creatorCarla D. F. Sousa
dc.creatorThaiane P. Moreira
dc.date.accessioned2024-07-19T21:40:34Z
dc.date.accessioned2025-09-08T23:16:00Z
dc.date.available2024-07-19T21:40:34Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.ebiom.2019.05.014
dc.identifier.issn2352-3964
dc.identifier.urihttps://hdl.handle.net/1843/71096
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEBioMedicine
dc.rightsAcesso Aberto
dc.subjectInfecção por Zika virus
dc.subjectAnticorpos Facilitadores
dc.subjectGestantes
dc.subjectImunidade
dc.titleIn-depth characterization of congenital Zika syndrome in immunocompetent mice: antibody-dependent enhancement and an antiviral peptide therapy
dc.typeArtigo de periódico
local.citation.epage529
local.citation.spage516
local.citation.volume44
local.description.resumoBackground: Zika virus (ZIKV) infection during pregnancy may cause major congenital defects, including microcephaly, ocular, articular and muscle abnormalities, which are collectively defined as Congenital Zika Syndrome. Here, we performed an in-depth characterization of the effects of congenital ZIKV infection (CZI) in immunocompetent mice. Methods: Pregnant dams were inoculated with ZIKV on embryonic day 5.5 in the presence or absence of a sub-neutralizing dose of a pan-flavivirus monoclonal antibody (4G2) to evaluate the potential role of antibody-dependent enhancement phenomenon (ADE) during short and long outcomes of CZI. Findings: ZIKV infection induced maternal immune activation (MIA), which was associated with occurrence of foetal abnormalities and death. Therapeutic administration of AH-D antiviral peptide during the early stages of pregnancy prevented ZIKV replication and death of offspring. In the post-natal period, CZI was associated with a decrease in whole brain volume, ophthalmologic abnormalities, changes in testicular morphology, and disruption in bone microarchitecture. Some alterations were enhanced in the presence of 4G2 antibody. Interpretation: Our results reveal that early maternal ZIKV infection causes several birth defects in immunocompetent mice, which can be potentiated by ADE phenomenon and are associated with MIA. Additionally, antiviral treatment with AH-D peptide may be beneficial during early maternal ZIKV infection.
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2352396419303159?via%3Dihub

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