Estuda da inflamação na esquizofrenia e no transtorno bipolar do humor: avaliação de citocinas pró-inflamatórias

Abstract

The inflammation consists essentially on recruitment of leukocytes and plasma proteins to the injured tissue so it can eliminate the injury agent. The inflammatory process leads to several mediators,including also, the cytokines. Those molecules are polypeptides that mediate and regulate the immune and inflammatory reactions. Recent researches have been relating the cytokines actions with the pathophysiology's bipolar mood disorder and schizophrenia. This way, the research in question objective was to review the literature across researches that made systemic levels dosages (serum or plasma) of the proinflammatory cytokines on schizophrenia and bipolar mood disorder. That way were researched articles based on MedLine data and Scielo with the key-words "Inflammation”, “Cytokines”, “Schizophrenia” and “Bipolar disorder”, being selected preferably those that were published from 2006 on. Ten works that evaluated the cytokines levels on patients with Bipolar Mood Disorder and Schizophrenia were identified. The research in question suggests the patients with Schizophrenia and those with Bipolar Mood Disorder present high levels of cytokines proinflammatory and these changes can be related with the pathophysiology of those psychiatric disorders.