Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast

Página do item simplificado
dc.creatorÁtila Duque Rossi
dc.creatorAmilcar Tanuri
dc.creatorMilton Ozório Moraes
dc.creatorRenato Santana de Aguiar
dc.creatorConstantine Stratakis
dc.creatorCynthia Chester Cardoso
dc.creatorFabio Rueda Faucz
dc.creatorAdriana Melo
dc.creatorGirlene Souza de Azevedo
dc.creatorPaula Pezzuto
dc.creatorOhanna Cavalcanti de Lima Bezerra
dc.creatorFernanda Saloum de Neves Manta
dc.creatorTamiris Azamor
dc.creatorBruno Luiz Fonseca Schamber-Reis
dc.date.accessioned2023-07-17T17:41:44Z
dc.date.accessioned2025-09-09T00:49:01Z
dc.date.available2023-07-17T17:41:44Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.3390/v13112253
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/1843/56403
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofViruses
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectPolimorfismo
dc.subject.otherZika
dc.subject.otherType III interferon
dc.subject.otherPolymorphism
dc.subject.otherCongenital Zika syndrome
dc.subject.otherGenetic susceptibility
dc.titleAssociation between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
dc.typeArtigo de periódico
local.citation.epage6
local.citation.issue11
local.citation.spage1
local.citation.volume13
local.description.resumoAbstract: Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at IFNL genes are associated with CZS, 52 women infected with ZIKV during pregnancy were enrolled in a case–control association study. A total of 28 women were classified as cases and 24 as controls based on the presence or absence of CZS in their infants, and seven Interferon-λ non-coding SNPs (rs12980275, rs8099917, rs4803217, rs4803219, rs8119886, rs368234815, rs12979860) were genotyped. The results of logistic regression analyses show an association between the G allele at rs8099917 and increased susceptibility to CZS under a log-additive model (adjustedOR = 2.80; 95%CI = 1.14–6.91; p = 0.02), after adjustment for trimester of infection and genetic ancestry. These results provide evidence of an association between Interferon-λ SNPs and CZS, suggesting rs8099917 as a promising candidate for further studies on larger cohorts.
local.identifier.orcidhttps://orcid.org/0000-0001-6235-8807
local.identifier.orcidhttps://orcid.org/0000-0003-0570-750X
local.identifier.orcidhttps://orcid.org/0000-0003-2653-0037
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0002-4058-5520
local.identifier.orcidhttps://orcid.org/0000-0001-7959-9842
local.identifier.orcidhttps://orcid.org/0000-0001-9570-8244
local.identifier.orcidhttps://orcid.org/0000-0002-0798-778X
local.identifier.orcidhttps://orcid.org/0000-0002-4047-2091
local.identifier.orcidhttps://orcid.org/0000-0002-7640-1463
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1999-4915/13/11/2253

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast.pdf
Tamanho:
288.19 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG