Gastroschisis prognostic score predicts high-risk newborns with gastroschisis in a middle-income country

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dc.creatorFabiobotelho
dc.creatorMarcelo e. Miranda
dc.creatorRenan Farias r. Viana
dc.creatorSherif Galal s. Emil
dc.creatorPramod s. Puligandla
dc.creatorVivian Resende
dc.creatorBernardo a. Campos
dc.creatorPaulo Custódio Furtado Cruzeiro
dc.creatorClecio Picarro
dc.creatorRicardo Paixao
dc.date.accessioned2023-05-12T19:36:58Z
dc.date.accessioned2025-09-09T01:33:00Z
dc.date.available2023-05-12T19:36:58Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.jamcollsurg.2021.08.399
dc.identifier.issn10727515
dc.identifier.urihttps://hdl.handle.net/1843/53218
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the American College of Surgeons
dc.rightsAcesso Aberto
dc.subjectGastrosquise
dc.subjectPaíses em Desenvolvimento
dc.subjectBrasil
dc.subject.otherGastrosquise
dc.subject.otherPaíses em Desenvolvimento
dc.titleGastroschisis prognostic score predicts high-risk newborns with gastroschisis in a middle-income country
dc.typeArtigo de periódico
local.citation.epagee149
local.citation.issue5
local.citation.spagee148
local.citation.volume233
local.description.resumoINTRODUCTION: The Gastroschisis Prognostic Score (GPS) stratifies patients as high or low-risk based on the visual assessment of intestinal matting, atresia, perforation, or necrosis shortly after birth. Its applicability to low and middle-income settings remains unknown. This study aimed to validate the GPS as a prognostic tool in a public hospital within a middle-income country. METHODS: With REB approval, we conducted a prospective study of all newborns with gastroschisis in a Brazilian neonatal public hospital from 2015-2019. Infants were stratified into low and high-risk cohorts based on the GPS. In addition to basic demographics, data collected included duration of parenteral nutrition (TPN), mechanical ventilation (MV), length of stay (LOS), sepsis, and mortality. Univariate and multivariate analyses were conducted to identify which outcomes the GPS independently predicted.RESULTS: Sixty-one newborns with gastroschisis were treated in our center. The mean birth weight, gestational age, and 5’ Apgar score were 2258g, 36weeks, and 9. Accordingly to the GPS, 24 infants (39.3%) were identified as low-risk and 37 (60.7%) as high-risk. The high-risk group presented with prolonged use of TPN (p<0.001), MV (p<0.001), and LOS (p:0.002). There was no association between GPS with sepsis or mortality in this study. CONCLUSION: This is the first study that validates the GPS as a prognostic tool in a middle-income country. Several important outcome measures were predicted by the GPS allowing for better parental counseling and resource allocation. The GPS is a reliable tool that can be used in various resource settings.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1072751521016471

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