Evaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration

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dc.creatorDébora Cristina Sampaio de Assis
dc.creatorGuilherme Resende da Silva
dc.creatorIsabela Pereira Lanza
dc.creatorAna Cláudia Dos Santos Rossi Ribeiro
dc.creatorÂngela Maria Quintão Lana
dc.creatorLeonardo José Camargos Lara
dc.creatorTadeu Chaves de Figueiredo
dc.creatorSilvana de Vasconcelos Cançado
dc.date.accessioned2023-07-17T17:34:41Z
dc.date.accessioned2025-09-09T01:03:24Z
dc.date.available2023-07-17T17:34:41Z
dc.date.issued2016-11-15
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0166402
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/56395
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLoS ONE
dc.rightsAcesso Aberto
dc.subjectZootecnia
dc.titleEvaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration
dc.typeArtigo de periódico
local.citation.epage14
local.citation.issue11
local.citation.spagee0166402
local.citation.volume11
local.description.resumoThe depletion times of enrofloxacin and its metabolite ciprofloxacin as well as sulfaquinoxaline and oxytetracycline were evaluated in broiler chickens that had been subjected to pharmacological treatment. The presence and residue levels of these drugs in muscle tissue were evaluated using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method that was validated in this work. The results showed the presence of all antimicrobial residues; however, the presence of residues at concentrations higher than the drugs’ maximum residue limit (MRL) of 100 μg kg-1 was found only during the treatment period for oxytetracycline and until two days after discontinuation of the medication for enrofloxacin, ciprofloxacin and sulfaquinoxaline. It was concluded that the residues of all antimicrobials were rapidly metabolized from the broiler muscles; after four days of withdrawal, the levels were lower than the limit of quantification (LOQ) of the method for the studied analytes.
local.identifier.orcidhttps://orcid.org/0000-0003-0066-6198
local.publisher.countryBrasil
local.publisher.departmentVET - DEPARTAMENTO DE TECNOLOGIA E INSPEÇÃO DE PRODUTOS DE ORIGEM ANIMAL
local.publisher.departmentVET - DEPARTAMENTO DE ZOOTECNIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166402

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