Cell proliferation is associated with intensity of tumor budding in oral squamous cell carcinoma

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dc.creatorHelvécio Marangon Junior
dc.creatorPriscila Laiza Rubim Leão
dc.creatorVictória Vasconcellos Moreira Melo
dc.creatorÂngela Braga Caixeta
dc.creatorPaulo Eduardo Alencar Souza
dc.creatorMaria Cassia Ferreira de Aguiar
dc.creatorMartinho Campolina Rebello Horta
dc.date.accessioned2025-06-13T19:56:58Z
dc.date.accessioned2025-09-08T23:33:42Z
dc.date.available2025-06-13T19:56:58Z
dc.date.issued2018-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12653
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/82956
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectCell proliferation
dc.subjectMouth neoplasms
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectEvaluation study
dc.subjectAssociation
dc.subject.otherCell proliferation
dc.subject.otherOral cancer
dc.subject.otherOral squamous cell carcinoma
dc.subject.otherTumor budding
dc.titleCell proliferation is associated with intensity of tumor budding in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage135
local.citation.issue2
local.citation.spage128
local.citation.volume47
local.description.resumoBackground: Tumor budding is a morphological marker of cancer invasion, defined as the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. This study aimed to evaluate the association between intensity of tumor budding and cell proliferation in oral squamous cell carcinoma (OSCC). Methods: Immunohistochemistry was employed in 163 OSCC samples to detect the cell proliferation marker Ki-67 and multicytokeratin (to identify OSCC cells in tumor budding evaluation). The Mann-Whitney test was used to evaluate differences in the cell proliferation index between samples with high-intensity tumor budding and samples with low-intensity or no tumor budding. In samples with high-intensity tumor budding, the Wilcoxon test was used to evaluate differences in the cell proliferation index between the budding area and the area outside the budding. The chi-square test assessed the association between cell proliferation index and intensity of tumor budding. Results: The cell proliferation index was higher in samples with high-intensity tumor budding than in samples with low-intensity or no tumor budding (P < .05). Tumors with high-intensity tumor budding showed a higher cell proliferation index in the budding area than in the area outside the budding (P < .05). Finally, samples showing high-intensity tumor budding were associated with high cell proliferation index (P < .05). Conclusion: Cell proliferation is positively associated with intensity of tumor budding in OSCC. Moreover, in tumors showing high-intensity tumor budding, the budding area is the location of higher cell proliferation. These findings reinforce the hypothesis that tumor budding is associated with the biological behavior of OSCC.
local.identifier.orcidhttps://orcid.org/0000-0002-9709-6795
local.identifier.orcidhttps://orcid.org/0000-0003-0876-0568
local.identifier.orcidhttps://orcid.org/0000-0001-5166-1982
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0003-0192-5614
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12653

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