Comparative study of different histologic classifications in the degree of differentiation in endometrial adenocarcinoma

Página do item simplificado
dc.creatorAgnaldo Lopes Silva-filho
dc.creatorErika Becker s Xavier
dc.creatorEduardo Batista Cândido
dc.creatorRicardo Macarenco
dc.creatorMárcia c f Ferreira
dc.creatorMarcelo Antônio Pascoal Xavier
dc.creatorRayara a m Maciel
dc.creatorPaula Vieira Teixeira Vidigal
dc.date.accessioned2023-07-11T20:35:44Z
dc.date.accessioned2025-09-09T00:32:59Z
dc.date.available2023-07-11T20:35:44Z
dc.date.issued2016-08-02
dc.format.mimetypepdf
dc.identifier.doiDOI: 10.5301/tj.5000528
dc.identifier.issn03008916
dc.identifier.urihttps://hdl.handle.net/1843/56083
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTumori Journal
dc.rightsAcesso Restrito
dc.subjectDiagnóstico Diferencial
dc.subjectNeoplasias do Endométrio
dc.subjectImuno-Histoquímica
dc.subject.otherDifferential diagnosis
dc.subject.otherEndometrial carcinoma
dc.subject.otherImmunohistochemistry
dc.titleComparative study of different histologic classifications in the degree of differentiation in endometrial adenocarcinoma
dc.typeArtigo de periódico
local.citation.epage495
local.citation.issue5
local.citation.spage488
local.citation.volume102
local.description.resumoPurpose: To evaluate the concordance among the available histologic classifications for endometrial adenocarcinoma using interobserver and intraobserver agreement as well as the association of tumor histologic degree in the above mentioned classifications with cellular proliferation measured by Ki-67.Methods: Seventy women who underwent surgical treatment of endometrial adenocarcinoma with histologic confirmation of endometrioid type were included in the study. Two experienced pathologists randomly analyzed the slides in 3 distinct timeframes with a maximum of 25 slides/timeframe. Tumor slides were classified according to the degree of differentiation using 4 different classifications: International Federation of Gynecology and Obstetrics (FIGO), modified FIGO, Lax, and Alkushi. Results: Intraobserver agreement was reasonable for classification of FIGO (k 0.469 and 0.538), very good for modi fied FIGO (k 0.661 and 0.768), moderate for Lax classification (k 0.496 and 0.466), and moderate/good for Alkushi classification (k 0.528 and 0.736). Interobserver concordance was regular for FIGO classification (k = 0.271 and 0.343), good/moderate for modified FIGO classification (k = 0.661 and 0.522, respectively), regular/moderate for Lax classification (k = 0.258 and 0.465, respectively), and regular for Alkushi classification (k = 0.283 and 0.402).Conclusions: The prognostic value of histologic grading in endometrial carcinoma and its importance for a successful therapeutic plan have been documented repeatedly, but the best grading system, in terms of prognostication, reproducibility, ease of use, and universality (e.g., applicability to all tumor cell types), has not been unequivocally defined.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/10.5301/tj.5000528

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG