Congenital zika syndrome is associated with maternal protein malnutrition

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dc.creatorJimena Barbeito Andrés
dc.creatorA. D. Rossi
dc.creatorRodrigo V. Barbosa
dc.creatorC. K. N. Amorim
dc.creatorMichel. P. C. de Souza
dc.creatorLeila Chimelli
dc.creatorRenato Santana de Aguiar
dc.creatorPaula N. Gonzalez
dc.creatorFlávio Alves Lara
dc.creatorMárcia C. Castro
dc.creatorZoltán Molnár
dc.creatorPaula Pezzuto
dc.creatorRicardo Tadeu Lopes
dc.creatorMarcelo T. Bozza
dc.creatorJoão Lídio Vianez Júnior
dc.creatorC. G. Barbeito
dc.creatorPatricia Cuervo
dc.creatorMaria Bellio
dc.creatorAmilcar Tanuri
dc.creatorPatricia P. Garcez
dc.creatorLuiza M. Higa
dc.creatorAndré Alves Dias
dc.creatorJanaina Vasconcelos
dc.creatorT. M. P. Santos
dc.creatorJessica C. C. G. Ferreira
dc.creatorRaiane O. Ferreira
dc.creatorF. F. Dutra
dc.date.accessioned2025-01-22T20:42:40Z
dc.date.accessioned2025-09-09T01:21:03Z
dc.date.available2025-01-22T20:42:40Z
dc.date.issued2020-01-10
dc.format.mimetypepdf
dc.identifier.doihttps://DOI.10.1126/sciadv.aaw6284
dc.identifier.issn2375-2548
dc.identifier.urihttps://hdl.handle.net/1843/79412
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScience Advances
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectGravidez
dc.subjectGenética
dc.titleCongenital zika syndrome is associated with maternal protein malnutrition
dc.typeArtigo de periódico
local.citation.epage12
local.citation.issue2
local.citation.spage1
local.citation.volume6
local.description.resumoZika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments knownas congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggestingthat its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for theemergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship betweenundernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetentpregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We foundthat the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure andembryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seqanalysis reveals gene expression deregulation required for brain development in infected low-protein progeny.These results suggest that maternal protein malnutrition increases susceptibility to CZS.
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.science.org/doi/10.1126/sciadv.aaw6284

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