Extracapsular extension and tumor implants in lymph nodes with canine mammary carcinoma metastasis: Study of the impact on survival

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dc.creatorAline De B. Bassani Gonçalves
dc.creatorT. C. Reis de Pinho
dc.creatorF. A. O. Toledo
dc.creatorDébora Balabram
dc.creatorÊnio Ferreira
dc.creatorMarina Rios de Araújo Campos
dc.creatorGeovanni Dantas Cassali
dc.date.accessioned2023-08-09T20:18:21Z
dc.date.accessioned2025-09-08T22:53:26Z
dc.date.available2023-08-09T20:18:21Z
dc.date.issued2021-07-05
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.rvsc.2021.07.010
dc.identifier.issn0034-5288
dc.identifier.urihttps://hdl.handle.net/1843/57665
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofResearch in Veterinary Science
dc.rightsAcesso Restrito
dc.subjectNeoplasias Mamárias Animais
dc.subjectCães
dc.subjectMetástase Linfática
dc.subjectExtensão Extranodal
dc.subject.otherMammary carcinoma
dc.subject.otherDogs
dc.subject.otherLymph node metastasis
dc.subject.otherExtracapsular extension
dc.subject.otherTumor implant
dc.titleExtracapsular extension and tumor implants in lymph nodes with canine mammary carcinoma metastasis: Study of the impact on survival
dc.typeArtigo de periódico
local.citation.epage93
local.citation.spage87
local.citation.volume139
local.description.resumoRegional lymph node status impacts survival in dogs with malignant mammary tumors. However, few studies have evaluated extracapsular extension and tumor implants in regional lymph node metastases in dogs with mammary carcinoma. Therefore, 84 cases of mammary carcinomas with metastases in inguinal and/or axillary lymph nodes from female dogs of different breeds and a total of 139 metastatic lymph nodes were evaluated by routine histological staining. Clinical and pathological characteristics of primary tumors as well as the presence of extracapsular extension and tumor implants in the lymph nodes were analyzed, in addition to survival. One to 5 lymph nodes were evaluated in each case. Extracapsular extension and tumor implants were present in 17.9% and 39.3% of cases, respectively. The simultaneous presence of extracapsular extension and tumor implants were associated with an increased risk of death (hazard ratio 10.46). In addition, “special type carcinomas”, high histological grade (grade III), and presence of extracapsular extension associated with tumor implants were related to a worse prognosis and shorter survival times (p < 0.05). Based on these results, we highlight the importance of identifying extracapsular extension and tumor implants in dogs with metastatic mammary carcinomas, as they are associated with a higher risk of death and shorter survival
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0034528821002241?via%3Dihub

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