Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine

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dc.creatorDanuza Montijo Diniz
dc.creatorCélio Jose Castro Junior
dc.creatorCarlos Malamut
dc.creatorMarina Rios Araújo
dc.creatorAndrea Vidal Ferreira
dc.creatorJuliana Figueira Silva
dc.creatorMarta do Nascimento Cordeiro
dc.creatorMarcia Helena Borges
dc.creatorMarco Aurelio Romano Silva
dc.creatorMarcus Vinicius Gomez
dc.date.accessioned2023-11-06T20:41:18Z
dc.date.accessioned2025-09-08T23:57:00Z
dc.date.available2023-11-06T20:41:18Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fmolb.2021.770471
dc.identifier.issn2296-889X
dc.identifier.urihttps://hdl.handle.net/1843/60521
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Molecular Biosciences
dc.rightsAcesso Aberto
dc.subjectDor
dc.subjectMorfina
dc.subjectEncéfalo
dc.subject.otherP. E. T
dc.subject.otherPain
dc.subject.otherMorphine
dc.subject.otherPhα1β
dc.subject.otherBrain
dc.subject.other18F-FDG
dc.titleMapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage770471
local.citation.volume8
local.description.resumoPreclinical evidence suggests the potential of Phα1β, a toxin obtained from the venom of spider Phoneutria nigriventer, as a new analgesic drug. Molecular brain imaging techniques have afforded exciting opportunities to examine brain processes in clinical pain conditions. This paper aims to study the brain regions involved in the analgesic effects of Phα1β compared with Morphine, in a model of acute pain induced by formalin in Sprague Dawley rats. We used 18F-fluorodeoxyglucose as a metabolic radiotracer to perform brain imaging of rats pretreated with Phα1β or Morphine in a model of acute inflammatory pain caused by intraplantar injection of formalin. The rats’ hind paw’s formalin stimulation resulted in a brain metabolic increase at the bilateral motor cortex, visual cortex, somatosensory cortex, thalamus, and cingulate cortex.In rats treated with Phα1β, selective inhibition of unilateral motor cortex and cingulate cortex was observed. Morphine treatment leads to small and selective inhibition at the bilateral amygdala striatum and accumbens. Our results indicate that the analgesic effect of Phα1β and Morphine possesses a differential profile of central processing in the pain state.
local.identifier.orcidhttps://orcid.org/0000-0002-6558-4639
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fmolb.2021.770471/full

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