Neuropsychiatric syndromes in childhood-onset systemic lupus erythematosus

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dc.creatorFlávia Patrícia Sena Teixeirasantos
dc.creatorBruno Ramos Nascimento
dc.creatorDébora Cerqueira Calderaro
dc.creatorGilda Aparecida Ferreira
dc.creatorHumberto Corrêa da Silva Filho
dc.date.accessioned2023-07-19T20:13:11Z
dc.date.accessioned2025-09-09T00:19:39Z
dc.date.available2023-07-19T20:13:11Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1097/rhu.0000000000001029
dc.identifier.issn10761608
dc.identifier.urihttps://hdl.handle.net/1843/56767
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJCR: Journal of Clinical Rheumatology
dc.rightsAcesso Restrito
dc.subjectLúpus Eritematoso Sistêmico
dc.subjectMetanálise
dc.subject.otherChildhood
dc.subject.otherNeuropsychiatric
dc.subject.otherSystemic lupus
dc.subject.otherMeta-analysis
dc.titleNeuropsychiatric syndromes in childhood-onset systemic lupus erythematosus
dc.typeArtigo de periódico
local.citation.epage214
local.citation.issue5
local.citation.spage206
local.citation.volume27
local.description.resumoObjective: The aim of this study was to access the prevalence of 19 neuropsychiatric syndromes in childhood-onset systemic lupus erythematosus (cSLE), as defined by the American College of Rheumatology(ACR) in 1999, by performing a systematic review and meta-analysis of relevant publications.Methods: A literature search from April 1999 to March 2018 identified studies investigating neuropsychiatric syndromes in cSLE patients, applying 1999 ACR Case Definitions, with a sample of at least 20 patients. Case reports, small case series, reviews, articles that did not use 1999 ACR case definitions, and those with adult SLE patients were excluded. The methodological quality of the studies was determined through the Loney quality assessment. Prevalence estimates with a 95% confidence interval were combined using random-effect (DerSimonian-Laird) models.Results: A total of 143 articles were identified and 9 were included. In a population of 1463 cSLE patients, 351 (29.9%) presented 869 neuropsy chiatric cSLE events (2.48 events/patient). The results for each syndrome were headache (52.2%), seizure disorders (48.6%), cognitive dysfunction (32.9%), mood disorder (28.3%), psychosis (22.7%), cerebrovascular disease (19.5%), acute confusional state (15.7%), movement disorder (9.4%), anx iety disorder (7.2%), aseptic meningitis (5.1%), mononeuropathy single/ multiplex (4.9%), myelopathy (4.2%), demyelinating syndrome (3.2%),cranial neuropathy (2.7%), polyneuropathy (2.6%), Guillain-Barré syndrome (2.5%), autonomic disorder (1.9%), plexopathy (1.3%), and myasthenia gravis (1.3%).Conclusions: Neuropsychiatric syndromes are prevalent among cSLE patients. The most prevalent were headaches, seizures, cognitive dysfunction, mood disorders, and psychosis. Determining the prevalence of each neuropsychiatric syndrome in cSLE may improve clinical awareness of these potentially fatal and disabling conditions.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/jclinrheum/Abstract/2021/08000/Neuropsychiatric_Syndromes_in_Childhood_Onset.7.aspx

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