Extreme lymphocytosis in a dog with T-zone lymphoma

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dc.creatorBruna Voltolin de Sena
dc.creatorAdriano de Paula Sabino
dc.creatorPaulo Ricardo de Oliveira Paes
dc.creatorBárbara Correa de Mello
dc.creatorRodrigo dos Santos Horta
dc.creatorMariana de Pádua Costa
dc.creatorMarilia Martins Melo
dc.creatorReysla Maria da Silveira Mariano
dc.creatorRodolfo Cordeiro Giunchetti
dc.creatorAntonio Giuliano
dc.creatorFabiola de Oliveira Paes Leme
dc.date.accessioned2024-09-25T21:28:35Z
dc.date.accessioned2025-09-09T01:30:32Z
dc.date.available2024-09-25T21:28:35Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.5455%2FOVJ.2023.v13.i12.25
dc.identifier.issn2218-6050
dc.identifier.urihttps://hdl.handle.net/1843/76897
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOpen Veterinary Journal
dc.rightsAcesso Aberto
dc.subjectCitologia
dc.subjectCitometria de fluxo
dc.subjectImunofenotipagem
dc.subjectLinfoma
dc.subjectLinfocitose
dc.subject.otherCytology
dc.subject.otherFlow cytometry
dc.subject.otherImmunophenotyping
dc.subject.otherIndolent lymphoma
dc.subject.otherLymphocytosis
dc.titleExtreme lymphocytosis in a dog with T-zone lymphoma
dc.typeArtigo de periódico
local.citation.epage1768
local.citation.issue12
local.citation.spage1760
local.citation.volume13
local.description.resumoBackground: Canine T-zone lymphoma (TZL) is recognized as an indolent CD45-T cell lymphoma, with low aggressiveness and high overall survival. The diagnosis is obtained by histopathology and immunohistochemistry, but also by cytological examination of the lymph node associated with immunophenotyping. Lymphocytosis is commonly identified as around 10,000 cells/µl and may reach 30,760 cells/µl. Case Description: The present report describes a case of a female Golden Retriever, nine years old, with generalized lymphadenopathy. In the cytological examination of the superficial cervical lymph node, a monomorphic population of small, “clear cells” and “hand mirror” lymphocyte shape was suggestive of TZL. The leukogram showed intense leukocytosis (160,050 cells/μl) due to small clear cell lymphocytosis (152,048 cells/μl). The myelogram showed a myeloid:erythroid ratio of 2:3; with a pyramidal distribution of cell types and the presence of 22.8% of lymphocytes in the differential count. Bone marrow, peripheral blood, and lymph node immunophenotyping resulted in lymphocyte gates with 97.3% to 99.5% CD5+, predominantly CD4-, CD8-, and CD45- confirming the diagnosis of TZL with associated leukemia. Treatment with chlorambucil and prednisolone was started. During the first month, the lymphocytosis remained above 200,000 cells/uL. After four months of treatment, there was a decrease in lymphocytes, which progressively reached a count of 10,800 cells/ul in the eleventh month. Conclusion: In the literature, lymphocytosis above 30,760 cells/μl has not been observed in TZLs. Thus, it is believed that this is the first report of extreme lymphocytosis with a slow response to chemotherapy.
local.identifier.orcidhttps://orcid.org/0000-0002-2396-7412
local.identifier.orcidhttps://orcid.org/0000-0001-8562-8689
local.identifier.orcidhttps://orcid.org/0000-0002-1366-7352
local.identifier.orcidhttps://orcid.org/0000-0002-9885-4498
local.identifier.orcidhttps://orcid.org/0000-0003-3630-6776
local.identifier.orcidhttps://orcid.org/0000-0001-6591-7934
local.identifier.orcidhttps://orcid.org/0000-0003-4181-7546
local.identifier.orcidhttps://orcid.org/0000-0002-4013-0147
local.publisher.countryBrasil
local.publisher.departmentVETER - ESCOLA DE VETERINARIA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824099/

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