Effect of Dexmedetomidine Low Doses with or without Midazolam in Cats: Clinical, Hemodynamic, Blood Gas Analysis, and Echocardiographic Effects

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dc.creatorMarina Lopes Castro
dc.creatorBruna Maia Cerqueira Câmara
dc.creatorMaira Souza Oliveira Barreto
dc.creatorRaphael Rocha Wenceslau
dc.creatorAndressa Karollini e Silva
dc.creatorNatália Fagundes
dc.creatorRenata Andrade Silva
dc.creatorEutálio Luiz Mariani Pimenta
dc.creatorSuzane Lilian Beier
dc.date.accessioned2024-01-03T16:42:32Z
dc.date.accessioned2025-09-09T00:33:08Z
dc.date.available2024-01-03T16:42:32Z
dc.date.issued2022-11-24
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/2022/9613721
dc.identifier.issn1687-6970
dc.identifier.urihttps://hdl.handle.net/1843/62433
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnesthesiology Research and Practice
dc.rightsAcesso Aberto
dc.subjectDexmedetomidina
dc.subjectMidazolam
dc.subjectGatos
dc.subjectHemodinâmica
dc.subject.otherDexmedetomidina
dc.subject.otherMidazolam
dc.subject.otherGatos
dc.subject.otherHemodinâmica
dc.titleEffect of Dexmedetomidine Low Doses with or without Midazolam in Cats: Clinical, Hemodynamic, Blood Gas Analysis, and Echocardiographic Effects
dc.typeArtigo de periódico
local.citation.epage16
local.citation.spage9613721
local.citation.volume2022
local.description.resumoObjectives. The aim of the study is to compare the sedative, cardiorespiratory, echocardiographic, and blood gas effects of dexmedetomidine and methadone associated or not with midazolam for restraint chemistry in cats. Methods. Eighteen healthy young cats (4.06 ± 0.48 kg) were randomly sedated with two protocols, through the intramuscular route: dexmedetomidine (5 µg.kg−1), methadone (0.3 mg. kg−1) and midazolam (0.3 mg. kg−1) (DMTM, n = 9), or dexmedetomidine (7.5 µg.kg−1) and methadone (0.3 mg. kg−1) (DMT, n = 9). The cardiorespiratory parameters were measured at baseline, 5 and 10 minutes after pharmacological latency. The sedation, analgesia, and muscle relaxation scores were assessed before and 5 minutes after pharmacological latency, while arterial blood gas analysis and echocardiography were assessed before and after 10 or 15 minutes, respectively. Results. There was no difference between the protocols regarding the cardiorespiratory, blood gas, and echocardiographic parameters used. The scores for sedation, analgesia, and muscle relaxation also did not differ between the protocols, with the degree of sedation, analgesia, and myorelaxation considered satisfactory in both groups. A significant decrease in heart rate (HR) was observed after administration of the sedative protocols, reaching a maximum reduction at T10 (46% and 53% reduction in the DMT and DMTM groups, respectively). The reduction in HR had an impact on echocardiographic parameters such as CO, which decreased 53% and 56% in the DMT and DMTM groups, respectively. There was a significant reduction in PaO2, SaO2, ejection fraction, and fractional shortening in both protocols. SpO2 decreased significantly after 5 minutes of sedation in the DMT group, but with a minimum mean SpO2 of 92% in T5. The respiratory rate decreased significantly at 5 and 10 minutes in the DMTM group, while PaCO2 increased in both groups, indicating respiratory depression caused by the drugs. Conclusions and Relevance. The study pointed out that both sedative protocols can be recommended for clinical sedation of young and healthy cats in the doses used. However, both protocols resulted in cardiorespiratory depression in cats and also the particularities of the animals should be evaluated regarding reducing cardiac output by more than 50%.
local.identifier.orcidhttps://orcid.org/0000-0003-0616-3559
local.identifier.orcidhttps://orcid.org/0000-0003-3501-611X
local.publisher.countryBrasil
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.departmentVET - DEPARTAMENTO DE ZOOTECNIA
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/arp/2022/9613721/

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