First report of collapsing variant of focal segmental glomerulosclerosis triggered by arbovirus: dengue and Zika virus infection

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dc.creatorStanley de Almeida Araújo
dc.creatorThiago Macedo e Cordeiro
dc.creatorAndré Rolim Belisário
dc.creatorRoberto Ferreira de Almeida Araújo
dc.creatorPaula Eillanny Silva Marinho
dc.creatorErna Geessien Kroon
dc.creatorDanilo Bretas de Oliveira
dc.creatorMauro Martins Teixeira
dc.creatorAna Cristina Simões e Silva
dc.date.accessioned2025-02-10T21:06:50Z
dc.date.accessioned2025-09-09T00:58:51Z
dc.date.available2025-02-10T21:06:50Z
dc.date.issued2018-11-19
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1093/ckj/sfy104
dc.identifier.issn2048-8505
dc.identifier.urihttps://hdl.handle.net/1843/79842
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Kidney Journal
dc.rightsAcesso Aberto
dc.subjectArbovírus
dc.subjectDengue
dc.subjectInsuficiência Renal Crônica
dc.subjectVírus da Zika
dc.subject.otherArbovirus
dc.subject.otherChronic kidney disease
dc.subject.otherDengue infection
dc.subject.otherFocal segmental glomerulosclerosis
dc.subject.otherRenal histopahology
dc.titleFirst report of collapsing variant of focal segmental glomerulosclerosis triggered by arbovirus: dengue and Zika virus infection
dc.typeArtigo de periódico
local.citation.epage361
local.citation.issue3
local.citation.spage355
local.citation.volume12
local.description.resumoBackground. The collapsing variant of focal segmental glomerulosclerosis (FSGS) is the most aggressive form of FSGS and is characterized by at least one glomerulus with segmental or global collapse and overlying podocyte hypertrophy and hyperplasia. Viruses can act as aetiological agents of secondary FSGS. This study aims to establish an aetiological link between dengue virus (DENV) infection and the collapsing variant of FSGS and to analyse possible influences of the apolipoprotein 1 (APOL1) gene risk alleles on the disease. Methods. Biopsies and medical records were gathered from 700 patients of the Instituto de Nefropatologia, Belo Horizonte, Brazil. Screening for the collapsing variant of FSGS was performed and serological, immunohistochemical, tissue polymerase chain reaction (PCR) and genetic analysis were conducted. Results. Eight patients were identified with positive DENV serology and negative serological and/or tissue markers for hepatitis B virus, hepatitis C virus, Epstein–Barr virus, human immunodeficiency virus, cytomegalovirus and parvovirus B19. In PCR analysis, six patients had positive markers for DENV strain genetic material, one patient had positive markers for co-infection of Zika virus (ZIKV) and DENV and one patient had positive markers only for ZIKV infection. Six of the eight patients did not show risk alleles of the APOL1 gene. One patient had only one risk allele (G1) and the sample from another did not contain enough DNA for genetic analysis to be performed.
local.identifier.orcidhttps://orcid.org/0000-0001-9996-4405
local.identifier.orcidhttps://orcid.org/0000-0003-4933-6309
local.identifier.orcidhttps://orcid.org/0000-0003-0166-4258
local.identifier.orcidhttps://orcid.org/0000-0001-7082-0520
local.identifier.orcidhttps://orcid.org/0000-0002-3518-8491
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/ckj/article/12/3/355/5193070

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