Guaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal study

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dc.creatorPatricia Verónica Aulestia Viera
dc.creatorSávio Morato Lacerda Gontijo
dc.creatorAlinne Damásia Martins Gomes
dc.creatorRubén Dario Sinisterra Millán
dc.creatorRodney Garcia Rocha
dc.creatorMaría Esperanza Cortés Segura
dc.creatorMarinilce Fagundes dos Santos
dc.creatorMaria Aparecida Borsatti
dc.date.accessioned2023-11-24T19:30:32Z
dc.date.accessioned2025-09-08T23:46:22Z
dc.date.available2023-11-24T19:30:32Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s10006-019-00747-4
dc.identifier.issn1865-1569
dc.identifier.urihttps://hdl.handle.net/1843/61359
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral and Maxillofacial Surgery
dc.rightsAcesso Restrito
dc.subjectCiclodextrinas
dc.subjectCicatrização de feridas
dc.subjectAgentes antibacterianos
dc.subjectBoca - Cirurgia
dc.subjectOssos - Regeneração
dc.subjectAlveolite
dc.subjectSecagem por congelação
dc.subject.otherAntibacterial agent
dc.subject.otherCytotoxicity
dc.subject.otherDry socket
dc.subject.otherGuaiacol
dc.subject.otherOral surgery
dc.subject.otherAnimal study
dc.titleGuaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal study
dc.typeArtigo de periódico
local.citation.epage61
local.citation.issue1
local.citation.spage53
local.citation.volume23
local.description.resumoPurpose: Dry socket (DS) is one the most common and symptomatic post-extraction complications; however, no consensus on its treatment has been reached. This study aimed to develop a novel dressing material for DS containing the phenolic agent guaiacol and evaluate its biological properties. Methods: An inclusion complex of guaiacol and β-cyclodextrin (Gu/βcd) was prepared by freeze-drying. Its antibacterial activity over six oral bacteria was analyzed using the microdilution method, and its cytotoxicity in osteoblasts was assessed with the MTT assay. The alveolar healing process induced by Gu/βcd was evaluated histologically after the treatment of DS in rats. Results: βcd complexation potentiated Gu’s antibacterial effect and reduced its cytotoxicity in osteoblasts. Bone trabeculae were formed in the alveolar apices of rats treated with Gu/βcd by day 7. On day 14, woven bone occupied the apical and middle thirds of the sockets; on day 21, the entire alveolus was filled by newly formed bone, which was in a more advanced stage of repair than the positive control (Alvogyl™). Conclusion: The improvement in Gu’s biological properties in vitro and the rapid alveolar repair in comparison with Alvogyl™ in vivo demonstrated the benefits of the Gu/βcd complex as a future alternative for the treatment of DS.
local.identifier.orcidhttps://orcid.org/0000-0002-3860-2360
local.identifier.orcidhttps://orcid.org/0000-0002-7803-4345
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.identifier.orcidhttps://orcid.org/0000-0002-3257-3327
local.identifier.orcidhttps://orcid.org/0000-0002-1413-0004
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10006-019-00747-4

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