Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy

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dc.creatorVinicius Dias Wilson
dc.creatorClaire Thomas
dc.creatorEmilie Passerieux
dc.creatorGérald Hugon
dc.creatorFabien Pillard
dc.creatorAndré Gustavo Pereira de Andrade
dc.creatorSébastien Bommart
dc.creatorMarie-Christine Picot
dc.creatorJoël Pincemail
dc.creatorJacques Mercier
dc.creatorSandrine Arbogast
dc.creatorDalila Laoudj-Chenivesse
dc.date.accessioned2023-03-01T14:18:51Z
dc.date.accessioned2025-09-08T23:27:21Z
dc.date.available2023-03-01T14:18:51Z
dc.date.issued2018-01
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/j.2617-1619.2018.tb00002.x
dc.identifier.issn2617-1619
dc.identifier.urihttps://hdl.handle.net/1843/50561
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscle
dc.rightsAcesso Aberto
dc.subjectDistrofia muscular
dc.subjectEspectroscopia de infravermelho
dc.subjectImagem de ressonancia magnetica
dc.subjectContração muscular
dc.subjectEstresse oxidativo
dc.subject.otherFacioscapulohumeral muscular dystrophy
dc.subject.otherNear infrared spectroscopy
dc.subject.otherMagnetic resonance imaging
dc.subject.otherMaximal voluntary contraction
dc.subject.otherOxidative stress
dc.titleImpaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue1
local.citation.spage1
local.citation.volume1
local.description.resumoAims: Facioscapulohumeral muscular dystrophy (FSHD) causes progressive muscle weakness and loss. This study aims to compare changes in quadriceps oxygenation and hemodynamics during maximal voluntary quadriceps isometric contraction (MVCQ) and to determine the relationships between these parameters and systemic oxidative stress markers and muscle structural parameters and muscle volume in patients with FSHD and healthy controls. Methods and results: 17 patients with FSHD and 14 sedentary healthy controls were matched for age and physical activity level. Blood antioxidant status and stress markers were evaluated. The quadriceps tissue oxygenation index was evaluated by near infrared spectroscopy during MVCQ. Quadriceps volume was determined by magnetic resonance imaging. Quadriceps muscle samples were obtained to evaluate muscle fiber typology and mitochondria morphology by transmission electron microcopy (TEM). Groups were compared by the unpaired Student t-test or by the non-parametric Kruskal - Wallis test in case of skewed distributions with p<0.05. Associations were assessed by Spearman correlations. Compared to controls, patients with FSHD displayed a significantly lower local O2 consumption per second that was correlated with significantly lower MVCQ and systemic oxidative stress marker levels. Although no difference in muscle typology was observed between groups, TEM showed abnormal aggregation of mitochondria near blood capillaries in FSHD muscles. Conclusions: These results suggest that patients with FSHD have a lower O2 demand during MVCQ and that TOI measured by NIRS during MVC could be useful to determine the muscle oxidative capacity. Furthermore, these adaptations are related to the muscle structure reorganization linked to the occurrence of oxidative stress.
local.identifier.orcidhttps://orcid.org/0000-0003-0184-5438
local.identifier.orcidhttps://orcid.org/0000-0003-3381-9744
local.identifier.orcidhttp://orcid.org/0000-0003-3406-4558
local.identifier.orcidhttps://orcid.org/0000-0003-4204-7299
local.identifier.orcidhttps://orcid.org/0000-0001-5228-2255
local.identifier.orcidhttps://orcid.org/0000-0003-4356-9187
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/j.2617-1619.2018.tb00002.x

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