A new theranostic system for bone disorders: functionalized folate-MDP hydroxyapatite nanoparticles with radiolabeled copper-64

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dc.creatorMarcelo Fernandes Cipreste
dc.creatorWagner da Nova Mussel
dc.creatorJuliana Batista da Silva
dc.creatorMaria Betânia de Freitas Marques
dc.creatorRonaldo Junio Campos Batista
dc.creatorPedro Lana Gastelois
dc.creatorWaldemar Augusto de Almeida Macedo
dc.creatorEdésia Martins Barros de Sousa
dc.date.accessioned2022-05-19T20:21:24Z
dc.date.accessioned2025-09-08T23:22:09Z
dc.date.available2022-05-19T20:21:24Z
dc.date.issued2020-11-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1016/j.matchemphys.2020.123265
dc.identifier.issn0254-0584
dc.identifier.urihttps://hdl.handle.net/1843/41837
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMaterials Chemistry and Physics
dc.rightsAcesso Restrito
dc.subjectNanopartículas sintéticas de hidroxiapatita
dc.subjectCobre-64
dc.subject.otherTheranostic system
dc.subject.otherHydroxyapatite nanoparticles
dc.subject.otherCopper-64
dc.subject.otherMDP
dc.subject.otherFolate
dc.subject.otherMedronate
dc.titleA new theranostic system for bone disorders: functionalized folate-MDP hydroxyapatite nanoparticles with radiolabeled copper-64
dc.typeArtigo de periódico
local.citation.epage17
local.citation.spage1
local.citation.volume254
local.description.resumoHydroxyapatite nanoparticles have been investigated as biological agents for the treatment and diagnosis of bone diseases due to their properties, providing high affinity to bone tissues and also due to the possibility to chemically modify the surfaces of these nanoparticles to provide active targeting to bone tumors or other bone disorders. In this work, synthetic hydroxyapatite nanoparticles and their surface modifications with folic and medronic acid were studied. Copper-64 was produced by neutron irradiation in a TRIGA MARK I nuclear reactor, and the functionalized nanoparticles radiolabeled with this radioisotope. The multi-technique characterization includes FTIR, PXRD, TGA, DSC, CHN, Zeta potential, XPS, SEM, TEM, and Gamma spectroscopy. Furthermore, the evaluation of the chemical interaction stability was through leaching tested for efficiency. The results indicate that folic and medronic acids can be covalently bonded to HA surface, producing a new material not yet described in the literature, been stably attached to hydroxyapatite nanoparticle surfaces, able to provide active targeting for bone disorders. The complexation of copper-64 provides high radiochemistry purity, although the specific activity must be improved.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0254058420306350

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