Comparison of the effects of monastrol and oxomonastrol on human hepatoma cell line HepG2/C3A

Página do item simplificado
dc.creatorLilian Areal Marques
dc.creatorSimone Cristine Semprebon
dc.creatorDaniele Sartori
dc.creatorÂngelo de Fátima
dc.creatorLúcia Regina Ribeiro
dc.creatorMário Sérgio Mantovani
dc.date.accessioned2024-07-12T19:55:45Z
dc.date.accessioned2025-09-08T22:55:31Z
dc.date.available2024-07-12T19:55:45Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.21873/anticanres.11434
dc.identifier.issn1791-7530
dc.identifier.urihttps://hdl.handle.net/1843/70470
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnticancer Research
dc.rightsAcesso Aberto
dc.subjectMorfologia
dc.subjectQuímica
dc.subjectAgentes antineoplásicos
dc.subjectApoptose
dc.subjectTestes biológicos
dc.subjectMicroscopia de fluorescência
dc.subjectCâncer - Quimioterapia
dc.subject.otherMonastrol
dc.subject.otherOxo-monastrol
dc.subject.otherHuman hepatoma cell line
dc.subject.otherAnticancer activity
dc.titleComparison of the effects of monastrol and oxomonastrol on human hepatoma cell line HepG2/C3A
dc.typeArtigo de periódico
local.citation.epage1204
local.citation.issue3
local.citation.spage1197
local.citation.volume37
local.description.resumoMonastrol and its analog oxomonastrol differ by replacement of the sulfur atom present in monastrol to an oxygen atom in oxomonastrol. Monastrol inhibits the mitotic kinesin family member 11 (EG5), which has been studied for its potential use in cancer therapy. The aim of this study was to investigate the effect of monastrol and oxomonastrol on HepG2/C3A cells. Our results showed that monastrol induced DNA damage, reduced cell proliferation, and up-regulated the cytochrome P450 family 1 subfamily A member 1 (CYP1A1) mRNA levels. However, oxomonastrol was cytotoxic only at the highest concentrations used, without reducing cell proliferation and viability. Moreover, no genotoxic damage or alteration of levels of mRNA were found. Our results suggest that monastrol has greater antiproliferative activity compared to oxomonastrol, and this effect is probably related to the DNA damage induced by monastrol and its possible bioactivation demonstrated by the increase in CYP1A1 mRNA expression. Moreover, these effects appear to be related to the presence of the sulfur atom in its structure.
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0002-7550-8509
local.identifier.orcidhttps://orcid.org/0000-0002-0465-9932
local.identifier.orcidhttps://orcid.org/0000-0002-9857-8681
local.identifier.orcidhttps://orcid.org/0000-0001-5268-6508
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://ar.iiarjournals.org/content/37/3/1197/tab-article-info

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Comparison of the Effects of Monastrol and Oxomonastrol.pdf
Tamanho:
274.51 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG