MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study

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dc.creatorGleyson Kleber do Amaral Silva
dc.creatorVivian Petersen Wagner
dc.creatorLaryssa Moura Dias
dc.creatorBruno Augusto Linhares Almeida Mariz
dc.creatorFelipe Paiva Fonseca
dc.creatorAna Lúcia Carrinho Ayroza Rangel
dc.creatorVirgilio Gonzales Zanella
dc.creatorRogério Moraes Castilho
dc.creatorManoela Domingues Martins
dc.creatorPablo Agustin Vargas
dc.date.accessioned2023-11-16T21:18:37Z
dc.date.accessioned2025-09-09T01:32:26Z
dc.date.available2023-11-16T21:18:37Z
dc.date.issued2022-02-20
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.4317%2Fmedoral.25138
dc.identifier.issn1698-6946
dc.identifier.urihttps://hdl.handle.net/1843/61014
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMed Oral Patol Oral Cir Bucal
dc.rightsAcesso Aberto
dc.subjectTumores
dc.subjectBiomarcadores
dc.subjectGlândulas Salivares
dc.subjectReparo do DNA
dc.subjectNeoplasias
dc.subject.otherSalivary Gland Neoplasms
dc.subject.otherSalivary gland cancer
dc.subject.otherDNA-repair
dc.subject.otherBiomarkers
dc.subject.otherPrognosis
dc.titleMutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study
dc.typeArtigo de periódico
local.citation.epagee173
local.citation.issue2
local.citation.spagee164
local.citation.volume27
local.description.resumoBackground Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutSα (hMSH2-hMSH6) and MutSβ (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival. Material and Methods Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3-hMSH6 expression, respectively. Results hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed. Conclusions Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT.
local.identifier.orcidhttps://orcid.org/0000-0002-6657-4547
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898574/

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