Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress

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dc.creatorÁtila Duque Rossi
dc.creatorHugo José Alves
dc.creatorHelena Toledo Scheid
dc.creatorDébora Souza Faffe
dc.creatorRafael Mello Galliez
dc.creatorRenata Eliane de Ávila
dc.creatorGustavo Gomes Resende
dc.creatorMauro Martins Teixeira
dc.creatorOrlando da Costa Ferreira Júnior
dc.creatorTerezinha Marta Castineiras
dc.creatorRenan Pedra Souza
dc.creatorJoão Locke Ferreira de Araújo
dc.creatorAmilcar Tanuri
dc.creatorRenato Santana de Aguiar
dc.creatorShana Priscila Coutinho Barroso
dc.creatorCynthia Chester Cardoso
dc.creatorTailah Bernardo de Almeida
dc.creatorMarcelo Ribeiro-alves
dc.creatorCamila de Almeida Velozo
dc.creatorJéssica Maciel de Almeida
dc.creatorIsabela de Carvalho Leitão
dc.creatorSâmila Natiane Ferreira
dc.creatorJéssica da Silva Oliveira
dc.date.accessioned2023-07-15T00:20:58Z
dc.date.accessioned2025-09-09T01:17:20Z
dc.date.available2023-07-15T00:20:58Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1038/s41598-021-88944-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/56358
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectDesconforto respiratorio
dc.subject.otherCOVID-19
dc.subject.otherSARS-CoV-2
dc.subject.otherRespiratory distress
dc.titleAssociation between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress
dc.typeArtigo de periódico
local.citation.issue9658
local.citation.volume11
local.description.resumoACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case–control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-19 patients with respiratory distress requiring oxygen support (N = 38) and controls were those with mild to moderate symptoms of the disease who did not need oxygen therapy along the entire clinical course (N = 175). ACE2 and TMPRSS2 mRNA levels were evaluated in nasopharyngeal swab samples by RT-qPCR and logistic regression analyzes were applied to estimate associations with respiratory outcomes. ACE2 and TMPRSS2 levels positively correlated with age, which was also strongly associated with respiratory distress. Increased nasopharyngeal ACE2 levels showed a protective effect against this outcome (adjOR = 0.30; 95% CI 0.09–0.91), while TMPRSS2/ACE2 ratio was associated with risk (adjOR = 4.28; 95% CI 1.36–13.48). On stepwise regression, TMPRSS2/ACE2 ratio outperformed ACE2 to model COVID-19 severity. When nasopharyngeal swabs were compared to bronchoalveolar lavages in an independent cohort of COVID-19 patients under mechanical ventilation, similar expression levels of these genes were observed. These data suggest nasopharyngeal TMPRSS2/ACE2 as a promising candidate for further prediction models on COVID-19.
local.identifier.orcidhttps://orcid.org/0000-0001-6235-8807
local.identifier.orcidhttps://orcid.org/0000-0003-1450-0148
local.identifier.orcidhttps://orcid.org/0000-0002-5795-429X
local.identifier.orcidhttps://orcid.org/0000-0001-5255-5938
local.identifier.orcidhttps://orcid.org/0000-0003-0348-8374
local.identifier.orcidhttps://orcid.org/0000-0001-6566-9280
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0002-1970-8936
local.identifier.orcidhttps://orcid.org/0000-0002-4746-6049
local.identifier.orcidhttps://orcid.org/0000-0002-9479-4432
local.identifier.orcidhttps://orcid.org/0000-0001-8338-8351
local.identifier.orcidhttps://orcid.org/0000-0001-7890-9255
local.identifier.orcidhttps://orcid.org/0000-0002-3695-4434
local.identifier.orcidhttps://orcid.org/0000-0002-8663-3364
local.identifier.orcidhttps://orcid.org/0000-0003-0105-1312
local.identifier.orcidhttps://orcid.org/0000-0002-0752-120X
local.identifier.orcidhttps://orcid.org/0000-0001-7919-612X
local.identifier.orcidhttps://orcid.org/0000-0002-2591-1818
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-021-88944-8

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