Exploring the hidden hot world of long non-coding RNAs in thermophilic fungus using a robust computational pipeline

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dc.creatorRoger G. Silva
dc.creatorPaulo P. Amaral
dc.creatorGlória R. Franco
dc.creatorAristóteles Góes-Neto
dc.date.accessioned2026-01-14T21:39:05Z
dc.date.issued2024-08-27
dc.identifier.doihttps://doi.org/10.1038/s41598-024-67975-x
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/1395
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso aberto
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectRNA Longo não Codificante
dc.subjectTranscriptoma
dc.subjectFungos
dc.titleExploring the hidden hot world of long non-coding RNAs in thermophilic fungus using a robust computational pipeline
dc.typeArtigo de periódico
local.citation.epage17
local.citation.spage1
local.citation.volume14
local.description.resumoLong noncoding RNAs (lncRNAs) are versatile RNA molecules recently identified as key regulators of gene expression in response to environmental stress. Our primary focus in this study was to develop a robust computational pipeline for identifying structurally identical lncRNAs across replicates from publicly available bulk RNA-seq datasets. In order to demonstrate the effectiveness of the pipeline, we utilized the transcriptome of the thermophilic fungus Thermothelomyces thermophilus and assessed the expression pattern of lncRNAs in conjunction with Heat Shock Proteins (HSP), a well-known protein family critical for the cell’s response to high temperatures. Our findings demonstrate that the identification of structurally identical transcripts among replicates in this thermophilic fungus ensures the reliability and accuracy of RNA studies, contributing to the validity of biological interpretations. Furthermore, the majority of lncRNAs exhibited a distinct expression pattern compared to HSPs. Our study contributes to advancing the understanding of the biological mechanisms comprising lncRNAs in thermophilic fungi.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS BIOLOGICAS
local.url.externahttps://www.nature.com/articles/s41598-024-67975-x

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