Evaluation of tumor-infiltrating lymphocytes in osteosarcomas of the jaws: a multicenter study

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dc.creatorPollianna Muniz Alves
dc.creatorAline Carvalho Batista
dc.creatorJosé Alcides Almeida Arruda
dc.creatorDiego Antônio Costa Arantes
dc.creatorSara Ferreira dos Santos Costa
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorFelipe Paiva Fonseca
dc.creatorRicardo Alves Mesquita
dc.creatorCassiano Francisco Weege Nonaka
dc.creatorElismauro Francisco Mendonça
dc.date.accessioned2023-10-02T19:15:48Z
dc.date.accessioned2025-09-08T23:33:06Z
dc.date.available2023-10-02T19:15:48Z
dc.date.issued2018-11-27
dc.identifier.doihttps://doi.org/10.1007/s00428-018-2499-6
dc.identifier.issn14322307
dc.identifier.urihttps://hdl.handle.net/1843/59066
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofVirchows Archiv
dc.rightsAcesso Restrito
dc.subjectImmunotherapy
dc.subjectMouth neoplasms
dc.subjectOsteosarcoma
dc.subjectTumor microenvironment
dc.subjectLymphocytes, tumor-infiltrating
dc.titleEvaluation of tumor-infiltrating lymphocytes in osteosarcomas of the jaws: a multicenter study
dc.typeArtigo de periódico
local.citation.epage207
local.citation.spage201
local.citation.volume474
local.description.resumoThe aim of the present study was to investigate the profile of tumor-infiltrating lymphocytes (TIL) in osteosarcomas of the jaws (OSJ). A total of 21 OSJ samples were analyzed in a retrospective and cross-sectional multicenter study. Immunohistochemistry was performed to determine the recognition of TIL such as CD4+, CD8+, granzyme B+ (GrB), programmed cell death protein+ (PD-1), and cytotoxic T lymphocyte-associated antigen 4+ (CTLA-4) in intratumoral and peripheral (stromal) regions. Positivity was determined based on the percentage and density of TIL+ per square millimeter [1 = absent (< 25 cells/mm2), 2 = low (25 to 130 cells/mm2), and 3 = high (> 130 cells/mm2)]. The association of TIL density with clinicopathologic data was determined by the Mann-Whitney test (p < 0.05). OSJ were positive for CD8+ cells in 45% (n = 9) of cases, for CD4+ cells in 30% (n = 6) of cases, and for CTLA-4+ in 4.8% (n = 1) of cases, with a score of 2 (low TIL) in all cases. All cases were negative for GrB and PD-1 (score 1). No association was observed between immune infiltrate and clinicopathologic findings. OSJ showed a microenvironment with low TIL, including failure of effectiveness of the antitumor immune response (absence of GrB+ cells), and few cells exhibited immunotherapeutic targets, such as CTLA-4 and PD-1
local.publisher.countryBrasil
local.publisher.departmentFAO - FACULDADE DE ODONTOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00428-018-2499-6

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