Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method

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dc.creatorMarina Ferrara de Resende
dc.creatorCleudiomar Inácio Lino
dc.creatorElaine Maria de Souza-Fagundes
dc.creatorJoão Vitor Paes Rettore
dc.creatorRenata Barbosa de Oliveira
dc.creatorRenata Adriana Labanca
dc.date.accessioned2022-04-06T23:35:44Z
dc.date.accessioned2025-09-08T23:57:34Z
dc.date.available2022-04-06T23:35:44Z
dc.date.issued2019-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doi10.1590/s2175-97902019000118218
dc.identifier.issn2175-9790
dc.identifier.urihttps://hdl.handle.net/1843/40864
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.rightsAcesso Aberto
dc.subjectDiabetes mellitus
dc.subjectCurcumina
dc.subject.otherOxidative stress
dc.subject.otherDiabetes mellitus
dc.subject.otherCurcumin
dc.subject.otherThiazole derivatives
dc.subject.otherDietary supplement
dc.titleAssessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method
dc.typeArtigo de periódico
local.citation.epage14
local.citation.spage1
local.citation.volume55
local.description.resumoDiabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bjps/a/9jk3vMCmNjfjMKrLLBWrfDL/?lang=en

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