Association between histopathological features of dysplasia in oral leukoplakia and loss of heterozygosity

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dc.creatorThiago Fonseca-Silva
dc.creatorMarina Goncalves Diniz
dc.creatorSílvia Ferreira de Sousa
dc.creatorRicardo Santiago Gomez
dc.creatorCarolina Cavalieri Gomes
dc.date.accessioned2025-05-30T21:49:34Z
dc.date.accessioned2025-09-09T00:21:37Z
dc.date.available2025-05-30T21:49:34Z
dc.date.issued2016-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/his.12746
dc.identifier.issn1365-2559
dc.identifier.urihttps://hdl.handle.net/1843/82677
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHistopathology
dc.rightsAcesso Restrito
dc.subjectLoss of heterozygosity
dc.subjectMouth neoplasms
dc.subjectHistology
dc.subjectCytology
dc.subjectEvaluation study
dc.subjectAssociation
dc.subjectArchitecture
dc.subject.otherDysplasia grading
dc.subject.otherLoss of heterozygosity
dc.subject.otherMolecular alterations
dc.subject.otherOral cancer
dc.subject.otherPotentially malignant oral disorders
dc.titleAssociation between histopathological features of dysplasia in oral leukoplakia and loss of heterozygosity
dc.typeArtigo de periódico
local.citation.epage460
local.citation.issue3
local.citation.spage456
local.citation.volume68
local.description.resumoAims: Oral leukoplakia (OL) dysplasia is graded on the basis of architectural and cytological features, and grade does not correlate well with malignant transformation. Loss of heterozygosity (LOH) profiles have been validated as risk predictors of OL malignant transformation. We aimed to assess whether the histological parameters used to grade dysplasia show different LOH profiles. Methods and results: Areas of epithelial dysplasia of 29 OL samples were microdissected, and LOH was assessed by use of a panel of 11 microsatellite markers located on chromosomes 3, 9, 11, and 17. Dysplasia was graded, and the cytological and architectural parameters were scored. Dysplasia was graded as mild in 18 samples, moderate in nine, and severe in two. The moderate/severe dysplasias and the mild dysplasias did not show different frequencies of allelic loss. Irregular epithelial stratification was associated with LOH at marker D3S1234 (3p14.2). In addition, the presence of drop-shaped rete ridges and premature keratinization in single cells showed associations with LOH at D9S162 (9p22) and P53 (17p13.1), respectively. Conclusions: We provide evidence that architectural and cellular changes in OL have different LOH patterns.
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/his.12746

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