The reduction of oxidative stress by nanocomposite fullerol decreases mucositis severity and reverts leukopenia induced by irinotecan

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dc.creatorRaquel Duque do Nascimento Arifa
dc.creatorLuiz Orlando Ladeira
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorMauro Martins Teixeira
dc.creatorDaniele da Glória de Souza
dc.creatorTalles Prosperi de Paula
dc.creatorMila Fernandes Moreira Madeira
dc.creatorRenata Lacerda de Lima
dc.creatorZélia Menezes Garcia
dc.creatorThiago Vinicius Ávila
dc.creatorVanessa Pinho
dc.creatorLuciola da Silva Barcelos
dc.creatorMauricio Veloso Brant Pinheiro
dc.date.accessioned2022-11-07T14:50:37Z
dc.date.accessioned2025-09-08T23:38:24Z
dc.date.available2022-11-07T14:50:37Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttp://dx.doi.org/10.1016/j.phrs.2016.03.004
dc.identifier.issn10436618
dc.identifier.urihttps://hdl.handle.net/1843/46975
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPharmacological Research
dc.rightsAcesso Restrito
dc.subjectFulerol
dc.subjectTumores
dc.subject.otherMucositis
dc.subject.otherLeukopenia
dc.subject.otherFullerol
dc.subject.otherEnterocytes
dc.titleThe reduction of oxidative stress by nanocomposite fullerol decreases mucositis severity and reverts leukopenia induced by irinotecan
dc.typeArtigo de periódico
local.citation.epage110
local.citation.spage102
local.citation.volume107
local.description.resumoIrinotecan is a useful chemotherapeutic agent for the treatment of several solid tumors. However, this therapy is associated with side effects, including leukopenia and mucositis. Reactive oxygen species (ROS) activate inflammatory pathways and contribute to Irinotecan-induced mucositis. Fullerol is a nanocomposite with anti-oxidant properties that may reduce tissue damage after inflammatory stimuli. In this paper, the effects of Fullerol and mechanisms of protection were investigated in a model of Irinotecan-induced mucositis. Mucositis was induced by an injection of Irinotecan per 4 days in C57BL/6. Fullerol or a vehicle was injected every 12 h. On day 7, the intestines were removed to evaluate histological changes, leukocyte influx, and the production of cytokines and ROS. Irinotecan therapy resulted in weight loss, an increased clinical score and intestinal injury. Treatment with Fullerol attenuated weight loss, decreased clinical score and intestinal damage. Irinotecan also induced increased ROS production in enterocytes, oxidative stress, IL-1β production, neutrophil and eosinophil influx in the ileum. Fullerol treatment decreased production of ROS in the enterocytes, oxidative stress, IL-1β production, neutrophil and eosinophil influx in the ileum. Irinotecan therapy also induced leukopenia in an ROS-dependent manner because leukopenia reverted in WT mice treated with Fullerol or Apocynin or in Gp91phox-/- mice. Mice treated with Irinotecan presented less melanoma tumor growth compared to the control group. Fullerol does not interfere in the anti-tumor action of Irinotecan. Fullerol has a great pharmacology potential to decreases the severity of mucositis and of leukopenia during chemotherapy treatment.
local.identifier.orcidhttps://orcid.org/0000-0002-4935-6070
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0002-7478-5934
local.identifier.orcidhttps://orcid.org/0000-0003-3120-5183
local.identifier.orcidhttps://orcid.org/0000-0002-1770-9978
local.identifier.orcidhttps://orcid.org/0000-0002-1600-0289
local.identifier.orcidhttps://orcid.org/0000-0003-1038-2324
local.identifier.orcidhttps://orcid.org/0000-0001-9133-4011
local.identifier.orcidhttps://orcid.org/0000-0001-5722-6260
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S104366181630038X?via%3Dihub

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