Soluble tumor necrosis factor receptors as predictors of 1-year mortality and renal dysfunction after liver transplantation

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dc.creatorBruno Salomemorais
dc.creatorAntonio Lucio Teixeira Junior
dc.creatorJader Freitas Maciel
dc.creatorAngela Aparecida Lima
dc.creatorIzabela Guimaraes Barbosa
dc.creatorMarcelo Dias Sanches
dc.date.accessioned2023-07-14T20:45:54Z
dc.date.accessioned2025-09-09T01:26:00Z
dc.date.available2023-07-14T20:45:54Z
dc.date.issued2016-02-01
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.trim.2016.01.006
dc.identifier.issn09663274
dc.identifier.urihttps://hdl.handle.net/1843/56309
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTransplant Immunology
dc.rightsAcesso Restrito
dc.subjectCitocinas
dc.subjectTransplante de Fígado
dc.subjectMortalidade
dc.subjectSíndrome de Fanconi
dc.subject.otherCytokines
dc.subject.otherLiver transplantation
dc.subject.otherMortality
dc.subject.otherRenal dysfunction
dc.subject.otherSoluble tumor necrosis factor receptor
dc.titleSoluble tumor necrosis factor receptors as predictors of 1-year mortality and renal dysfunction after liver transplantation
dc.typeArtigo de periódico
local.citation.epage33
local.citation.issue2016
local.citation.spage29
local.citation.volume35
local.description.resumoBackground: Several risk factors influence survival after liver transplantation (LT). Some research has demonstrated a relationship between soluble tumor necrosis factor receptors (sTNFRs) and worse clinical liver disease outcomes, but there are no data showing an association between sTNFRs and outcomes after LT. The primary aim of this study was to determine whether an association exists between perioperative sTNFRs and renal dysfunction or mortality after LT. Methods: Data were collected prospectively from 122 patients submitted to deceased-donor orthotopic LT. Blood samples were collected at seven different perioperative times and analyzed by ELISA. The statistical analysis included univariate analysis followed by logistic regression. The predictive value of significant variables was assessed using ROC curves. Results: One-month and 1-year LT survivals were 91% and 81%, respectively. Increased levels of soluble tumor necrosis factor receptor 1 (sTNF-R1) after 24 h of graft perfusion were associated with postoperative Renal Replacement Therapy (RRT) (OR 1.25) and 1-year mortality (OR 1.1). RRT was associated with 30-day and 1-year LT mortality, with OR 19.78 and 45.45, respectively. Conclusion: A higher sTNF-R1 level measured 24 h after graft perfusion is an independent predictor of RRT and 1-year mortality after LT.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0966327416300077?via%3Dihub

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