Type 1 diabetes mellitus: can coaching improve health outcomes?
| dc.creator | Tais Pereira Costa Magalhães | |
| dc.creator | Rodrigo Bastos Fóscolo | |
| dc.creator | Aleida Nazareth Soares | |
| dc.creator | Janice Sepúlveda Reis | |
| dc.date.accessioned | 2023-11-09T22:33:57Z | |
| dc.date.accessioned | 2025-09-09T01:03:11Z | |
| dc.date.available | 2023-11-09T22:33:57Z | |
| dc.date.issued | 2018 | |
| dc.format.mimetype | ||
| dc.identifier.doi | 10.20945/2359-3997000000058 | |
| dc.identifier.issn | 23593997 | |
| dc.identifier.uri | https://hdl.handle.net/1843/60757 | |
| dc.language | eng | |
| dc.publisher | Universidade Federal de Minas Gerais | |
| dc.relation.ispartof | Archives of Endocrinology and Metabolism | |
| dc.rights | Acesso Aberto | |
| dc.subject | Diabetes Mellitus, Type 1 | |
| dc.subject | Healt | |
| dc.subject | Self-Management | |
| dc.subject.other | Type 1 diabetes mellitus | |
| dc.subject.other | self-management | |
| dc.subject.other | health | |
| dc.title | Type 1 diabetes mellitus: can coaching improve health outcomes? | |
| dc.type | Artigo de periódico | |
| local.citation.epage | 489 | |
| local.citation.issue | 4 | |
| local.citation.spage | 485 | |
| local.citation.volume | 62 | |
| local.description.resumo | Objective:This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile.Materials and methods:D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated.Results:Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies | |
| local.publisher.country | Brasil | |
| local.publisher.department | MED - DEPARTAMENTO DE CLÍNICA MÉDICA | |
| local.publisher.initials | UFMG | |
| local.url.externa | https://www.scielo.br/j/aem/a/W3Cr6pMXfj4g5wf7J7CmSQd/?lang=en |