Effect of dietary supplementation with Tenebrio molitor wholemeal and fermented flour modulating adipose lipogenesis gene expression in obese mice

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dc.creatorBruna Viana Caldas
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorGuilherme Henrique Mendes Ribeiro
dc.creatorThiago Alves Xavier dos Santos
dc.creatorDanielly Araújo Nobre
dc.creatorRuann Janser Soares de Castro
dc.creatorDiego Vicente da Costa
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorValéria Mafra
dc.creatorJúnio Cota Silva
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2024-09-26T21:04:13Z
dc.date.accessioned2025-09-09T00:59:34Z
dc.date.available2024-09-26T21:04:13Z
dc.date.issued2022-11-28
dc.identifier.doihttps://doi.org/10.3920/JIFF2022.0070
dc.identifier.issn2352-4588
dc.identifier.urihttps://hdl.handle.net/1843/76927
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Insects as Food and Feed
dc.rightsAcesso Restrito
dc.subjectInsetos comestíveis
dc.subjectSíndrome metabólica
dc.subjectTenébrio
dc.subjectObesidade
dc.titleEffect of dietary supplementation with Tenebrio molitor wholemeal and fermented flour modulating adipose lipogenesis gene expression in obese mice
dc.typeArtigo de periódico
local.citation.epage635
local.citation.issue5
local.citation.spage625
local.citation.volume9
local.description.resumoThe use of insects recently emerged as an alternative source of high-quality animal protein for both animal and human food supplementation use with lower environmental impact. Recent evidence indicates that an insect-based diet provides an improved animal production mass gain and showed benefits for human health. The present study evaluated the dietary supplementation effect of the Tenebrio molitor fermented and wholemeal flour on the metabolism of diet-induced obese mice. Male Swiss mice were divided into 4 groups treated for 4 weeks as follows: standard diet, high-fat diet, high-fat diet + wholemeal flour and high-fat diet + fermented flour. The 15% wholemeal or fermented flour were added to the diet. Several parameters such as food/energy intake, body weight, adipose tissue weight, biochemical levels, adipose tissue histology and mRNA expression were evaluated. The main results showed that the inclusion of wholemeal and fermented T. molitor flour induced body weight loss, adiposity reduction and specific changes in biochemical and histological parameters. In addition, was observed significant changes in lipogenic gene expression. The insect flour negatively modulated the expression of the SREBP1α, CEBP1α, FAS, ACC gene and positively modulated PGC1α. In conclusion, the main findings showed the T. molitor flour potential use to improve dyslipidaemia and adiposity with beneficial effects on metabolic diseases.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.wageningenacademic.com/doi/10.3920/JIFF2022.0070

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