A review of the molecular profile of benign and malignant odontogenic lesions

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dc.creatorFilipe Fideles Duarte-Andrade
dc.creatorJéssica Gardone Vitório
dc.creatorThaís dos Santos Fontes Pereira
dc.creatorCarolina Cavaliéri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-08-29T20:25:18Z
dc.date.accessioned2025-09-09T00:25:09Z
dc.date.available2025-08-29T20:25:18Z
dc.date.issued2020-04
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2019.12.017
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/84740
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectOdontogenic tumors
dc.subjectOncogenes
dc.subjectGenes
dc.subjectMutation
dc.subjectPrognosis
dc.subjectDiagnosis
dc.titleA review of the molecular profile of benign and malignant odontogenic lesions
dc.typeArtigo de periódico
local.citation.epage368
local.citation.issue4
local.citation.spage357
local.citation.volume129
local.description.resumoOdontogenic cysts and tumors are heterogeneous lesions, originating from elements or remnants of the odontogenic apparatus. Although the majority of these lesions are benign and never undergo malignant transformation, rare malignant tumors may arise de novo or from benign precursors. The molecular basis of these lesions is still poorly understood. This article summarizes and discusses studies using small, medium, and large-scale and/or "-omic" techniques to describe the molecular characteristics of benign and malignant odontogenic lesions and briefly debates strategies to increase the use of "-omic" and multi-omic approaches or integrative analyses in the research of these lesions. A comprehensive understanding of the molecular aspects of odontogenic lesions by using large-scale approaches will enable us to refine the classification of this heterogeneous group of disorders and provide more accurate biomarkers for precise diagnosis, prognosis, and development of molecular tools in the management of patients with these conditions.
local.identifier.orcidhttps://orcid.org/0000-0003-0345-0376
local.identifier.orcidhttps://orcid.org/0000-0002-5009-6675
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440320300031?via%3Dihub

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