Metformin reduces lipogenesis markers in obese mice fed a low-carbohydrate and high-fat diet

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dc.creatorKarla Nayara de Oliveira Santana
dc.creatorDeborah Farias Lelis
dc.creatorKeila Lopes Mendes
dc.creatorJamille Fernandes Lula
dc.creatorAlanna Fernandes Paraíso
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorJohn David Feltenberger
dc.creatorJúnio Cota Silva
dc.creatorDiego Vicente da Costa
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-08-15T12:45:09Z
dc.date.accessioned2025-09-09T01:17:27Z
dc.date.available2022-08-15T12:45:09Z
dc.date.issued2016-11-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1007/s11745-016-4209-y
dc.identifier.issn1558-9307
dc.identifier.urihttps://hdl.handle.net/1843/44255
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLipids
dc.rightsAcesso Aberto
dc.subjectSíndrome metabólica
dc.subjectObesidade
dc.subjectTecido adiposo
dc.subjectÁcidos graxos na nutrição humana
dc.subjectHiperglicemia
dc.titleMetformin reduces lipogenesis markers in obese mice fed a low-carbohydrate and high-fat diet
dc.typeArtigo de periódico
local.citation.epage1384
local.citation.issue12
local.citation.spage1375
local.citation.volume51
local.description.resumoLipogenesis is the process by which fatty acids are synthesized. In metabolic syndrome, an insulin resistant state along with high plasma levels of free fatty acids (FFA) and hyperglycemia may contribute to the lipogenic process. The aim of the present study was to investigate the effects of oral administration of metformin on the expression of lipogenic genes and glycemic profile in mice fed with low-carbohydrate high-fat diet by evaluating their metabolic profile. SWISS male mice were divided into 4 groups (N = 7) that were fed with standard (ST), standard plus metformin (ST + MET), low-carbohydrate high-fat diet (LCHFD) and low-carbohydrate high-fat diet plus metformin (LCHFD + MET) (100 mg kg−1 diet) diets respectively. Food intake, body weight and blood parameters, such as glucose tolerance, insulin sensitivity, glucose, HDL-c, total cholesterol, triglycerides, ASL and ALT levels were assessed. Histological analyses were performed on hematoxylin and eosin-stained epididymal adipose tissue histological specimens. The expression levels of peroxisome proliferator-activated receptor (PPARγ), sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), were assessed by RT-PCR. This study showed that metformin decreased adipocyte area, body weight and food consumption in obese animals when compared to the standard group. Furthermore, the expression of lipogenic markers in adipose tissue were diminished in obese animals treated with metformin. This data showed that oral administration of metformin improved glucose and lipid metabolic parameters in white adipose tissue by reducing the expression of lipogenesis markers, suggesting an important clinical application of MET in treating obesity-related diseases in metabolic syndrome.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11745-016-4209-y

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