Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice

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dc.creatorDébora Romualdo Lacerda
dc.creatorKátia Anunciação Costa
dc.creatorAna Letícia Malheiros Silveira
dc.creatorDébora Fernandes Rodrigues
dc.creatorAlbená Nunes Silva
dc.creatorJosiana Lopes Sabino
dc.creatorVanessa Pinho
dc.creatorGustavo Batista de Menezes
dc.creatorDanusa Dias Soares
dc.creatorMauro Martins Teixeira
dc.creatorAdaliene Versiani Matos Ferreira
dc.date.accessioned2022-08-05T12:16:26Z
dc.date.accessioned2025-09-08T23:14:35Z
dc.date.available2022-08-05T12:16:26Z
dc.date.issued2019-10
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2019.06.006
dc.identifier.issn0955-2863
dc.identifier.urihttps://hdl.handle.net/1843/43998
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Nutritional Biochemistry
dc.rightsAcesso Restrito
dc.subjectJejum
dc.subjectObesidade
dc.subjectInflamação
dc.subjectCitocinas
dc.subjectCitocinas
dc.subjectTecido adiposo
dc.subjectPerda de peso
dc.subject.otherFasting
dc.subject.otherObesity
dc.subject.otherInflammation
dc.subject.otherCytokines
dc.subject.otherAdipose tissue
dc.subject.otherFat loss
dc.titleRole of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume72
local.description.resumoInflammation induced by obesity contributes to insulin resistance and atherosclerosis. Indeed, high levels of proinflammatory cytokines trigger chronic low-grade inflammation and promote detrimental metabolic effects in the adipose tissue. On the other hand, inflammation seems to control fat pad expansion and to have important functions on lipolysis and glucose metabolism. Thus, it is possible that inflammation may also drive fat pad loss, as seen during long-fast periods. Herein, we have used fasting as a strategy to induce weight loss and evaluate the possible role of inflammation on adipose tissue remodeling. Male BALB-c mice were fed with chow diet (lean mice) or with high-carbohydrate refined diet (mildly obese mice) for 8 weeks. After that, animals were subjected to 24 h of fasting. There was a 63% reduction of adiposity in lean mice following fasting. Furthermore, the adipose tissue was enriched of immune cells and had a higher content of IL-6, TNF-alpha, IL-10, TGF-β and CXCL-1. Interestingly, mildly obese mice, subjected to the same 24-h fasting period, lost only 33% of their adiposity. Following fasting, these mice did not show any increment in leukocyte recruitment and cytokine levels, as did lean mice. Our findings indicate that inflammation participates in fat mass loss induced by fasting. Although the chronic low-grade inflammation seen in obesity is associated with metabolic diseases, a lower inflammatory response triggered by fasting in mildly obese mice impairs fat pad mobilization.
local.identifier.orcidhttps://orcid.org/0000-0003-1052-0854
local.identifier.orcidhttps://orcid.org/0000-0002-5236-3124
local.identifier.orcidhttps://orcid.org/0000-0003-1038-2324
local.identifier.orcidhttps://orcid.org/0000-0001-9887-3616
local.identifier.orcidhttp://orcid.org/0000-0002-5705-8890
local.identifier.orcidhttps://orcid.org/0000-0003-2256-8652
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286318304303#:~:text=Our%20findings%20indicate%20that%20inflammation,mice%20impairs%20fat%20pad%20mobilization.

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