Common dysregulation of innate immunity pathways in human primary astrocytes infected with chikungunya, mayaro, oropouche, and zika viruses

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dc.creatorVictor Emmanuel Viana Geddes
dc.creatorEurico de Arruda Neto
dc.creatorAmilcar Tanuri
dc.creatorRenan Pedra Souza
dc.creatorIranaia Assunção-Miranda
dc.creatorSoniza Vieira Alves-Leon
dc.creatorLuciana Ferreira Romão
dc.creatorJorge Paes Barreto Marcondes de Souza
dc.creatorAna Tereza Ribeiro de Vasconcelos
dc.creatorRenato Santana de Aguiar
dc.creatorOtávio José Bernardes Brustolini
dc.creatorLiliane Tavares de Faria Cavalcante
dc.creatorFilipe Romero Rebello Moreira
dc.creatorFernando Luz de Castro
dc.creatorAna Paula de Campos Guimarães
dc.creatorAlexandra Lehmkuhl Gerber
dc.creatorCamila Menezes Figueiredo
dc.creatorLuan Pereira Diniz
dc.date.accessioned2025-01-22T21:02:06Z
dc.date.accessioned2025-09-09T00:48:20Z
dc.date.available2025-01-22T21:02:06Z
dc.date.issued2021-03-15
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fcimb.2021.641261
dc.identifier.issn2235-2988
dc.identifier.urihttps://hdl.handle.net/1843/79414
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Cellular and Infection Microbiology
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectChikungunya
dc.subjectImunidade
dc.subjectArbovírus
dc.subject.otherChikungunya
dc.subject.otherMayaro
dc.subject.otherOropouche
dc.subject.otherZika
dc.subject.otherInnate immunity
dc.subject.otherAstrocytes
dc.titleCommon dysregulation of innate immunity pathways in human primary astrocytes infected with chikungunya, mayaro, oropouche, and zika viruses
dc.typeArtigo de periódico
local.citation.epage17
local.citation.spage1
local.citation.volume11
local.description.resumoArboviruses pose a major threat throughout the world and represent a great burden in tropical countries of South America. Although generally associated with moderate febrile illness, in more severe cases they can lead to neurological outcomes, such as encephalitis, Guillain-Barré syndrome, and Congenital Syndromes. In this context astrocytes play a central role in production of inflammatory cytokines, regulation of extracellular matrix, and control of glutamate driven neurotoxicity in the central nervous system. Here, we presented a comprehensive genome-wide transcriptome analysis of human primary astrocytes infected with Chikungunya, Mayaro, Oropouche, or Zika viruses. Analyses of differentially expressed genes (DEGs), pathway enrichment, and interactomes have shown that Alphaviruses up-regulated genes related to elastic fiber formation and N-glycosylation of glycoproteins, with down-regulation of cell cycle and DNA stability and chromosome maintenance genes. In contrast, Oropouche virus up-regulated cell cycle and DNA maintenance and condensation pathways while down-regulated extracellular matrix, collagen metabolism, glutamate and ion transporters pathways. Zika virus infection only up-regulated eukaryotic translation machinery while down-regulated interferon pathways. Reactome and integration analysis revealed a common signature in down-regulation of innate immune response, antiviral response, and inflammatory cytokines associated to interferon pathway for all arboviruses tested. Validation of interferon stimulated genes by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) corroborated our transcriptome findings. Altogether, our results showed a co-evolution in the mechanisms involved in the escape of arboviruses to antiviral immune response mediated by the interferon (IFN) pathway.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE ZOOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.641261/full

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