Síntese e caracterização de complexos ternários de gálio(III) com 1,4-dihidroxiantraquinona e ligantes N,N-doadores como potenciais compostos antitumorais

Abstract

Metal complexes play a prominent role in the treatment of cancer. The search for new compounds that are more effective and cause fewer adverse effects on patients is of fundamental importance for the development of new treatments. Based on this vision, in this work two ternary gallium(III) complexes were synthesized and characterized with the ligands 1,4-dihydroxyanthraquinone (qnz) and 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen). The complexes [Ga2(qnz)(bpy)2](NO3)4, complex 1, and [Ga2(qnz)(phen)2](NO3)4, complex 2, were characterized by elemental analysis, infrared absorption spectroscopy, mass spectrometry (ESI-MS) and single-crystal X-ray diffraction, in the case of complex 1. The two complexes are dinuclear and have a similar structure, where the the anthracene ligand bridges two metal ions, which are also coordinated to two nitrogens of the α,α–diimines. As gallium compounds have known antitumor activity, the effect of the synthesized compounds on the growth of chronic myeloid leukemia cells was studied. The two complexes inhibit the growth of cancer cells at low concentrations.