Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus

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dc.creatorCaroline Pereiradomingueti
dc.creatorJéssica a. Fuzatto
dc.creatorRodrigo Bastos Fóscolo
dc.creatorJanice s. Reis
dc.creatorLuci m. Dusse
dc.creatorMaria Das Graças Carvalho
dc.creatorKarina b. Gomes
dc.creatorAna Paula Fernandes
dc.date.accessioned2023-11-09T22:24:30Z
dc.date.accessioned2025-09-08T22:55:59Z
dc.date.available2023-11-09T22:24:30Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.cca.2016.05.011
dc.identifier.issn00098981
dc.identifier.urihttps://hdl.handle.net/1843/60755
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsAcesso Aberto
dc.subjectDiabetes Mellitus, Type 1
dc.subjectCreatinine
dc.subjectCystatin C
dc.subjectAlbuminuria
dc.subject.otherD-Dimer
dc.subject.othertype 1 diabetes mellitus
dc.subject.otherCystatin C
dc.subject.otherCreatinine
dc.subject.otherAlbuminuria
dc.titleAssociation between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
dc.typeArtigo de periódico
local.citation.epage33
local.citation.issue1
local.citation.spage27
local.citation.volume62
local.description.resumoObjective: This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods: D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results: Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion: Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.20945/2359-3997000000003

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