Release of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spur

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dc.creatorGabriel Antônio dos Anjos Tou
dc.creatorJosé Messias Gomes
dc.creatorLuíza Santana de Oliveira Rinco
dc.creatorMonica Yamauti
dc.creatorIvana Márcia Alves Diniz
dc.creatorFabiane Pires
dc.creatorMarcella Emilia Petra Schmidt
dc.creatorHelvécio Costa Menezes
dc.creatorZenilda de Lourdes Cardeal
dc.creatorCarla Beatriz Grespan Bottoli
dc.creatorSoraia Macari
dc.date.accessioned2024-05-13T14:54:21Z
dc.date.accessioned2025-09-08T23:10:38Z
dc.date.available2024-05-13T14:54:21Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-7757-2022-0227
dc.identifier.issn1678-7765
dc.identifier.urihttps://hdl.handle.net/1843/68230
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Applied Oral Science
dc.rightsAcesso Aberto
dc.subjectCompostos orgânicos
dc.subjectResinas dentárias
dc.subjectCromatografia liquida de alta eficiencia
dc.subjectEspectrometria de massa
dc.subjectCromatografia a gás
dc.subject.otherMethacrylates
dc.subject.otherBisphenol-A glycidyl methacrylate
dc.subject.otherDibutyl phthalate
dc.subject.otherKeratinocytes
dc.subject.otherOpen bite
dc.titleRelease of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spur
dc.typeArtigo de periódico
local.citation.volume30
local.description.resumoTo evaluate the release of bisphenol-A glycidyl methacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA), bisphenol A (BPA), and phthalates of the composite resin used in the bonding of spurs applied in the treatment of children with anterior open bite and its effects on human keratinocytes. Methodology: Saliva samples of 22 children were collected before spur attachment (baseline) and 30 minutes (min) and 24 hours (h) after spur bonding. Analysis was performed using high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (HPLC–MS/ MS) and gas chromatography coupled to mass spectrometry (GC–MS). Standardized resin increments were added to three different dilutions of the cell culture medium. Keratinocytes (HaCaT) were cultivated in the conditioned media and evaluated for cell viability (MTT) and cell scratch assay. Results: The levels of BisGMA (1.74±0.27 μg/mL), TEGDMA (2.29±0.36 μg/mL), and BPA (3.264±0.88 μg/L) in the saliva after 30 min, in comparison to baseline (0±0 μg/mL, 0±0 μg/mL, and 1.15±0.21 μg/L, respectively), presented higher numbers. After 24 h, the levels of the monomers were similar to the baseline. Phthalates showed no significant difference among groups. HaCat cells showed increased viability and reduced cell migration over time after exposure to methacrylate-based resin composites. Conclusion: Resin composites, used to attach spurs in children with anterior open bite during orthodontic treatment, release monomers after polymerization and can influence the behavior of human keratinocytes, even at very low concentrations. Orthodontists should be aware of the risks of the resinous compounds release and preventive procedures should be held to reduce patient exposure.
local.identifier.orcidhttp://orcid.org/0000-0002-4697-5503
local.identifier.orcidhttp://orcid.org/0000-0003-3246-3301
local.identifier.orcidhttp://orcid.org/0000-0003-0675-9053
local.identifier.orcidhttp://orcid.org/0000-0002-0886-4407
local.identifier.orcidhttp://orcid.org/0000-0003-4261-0037
local.identifier.orcidhttp://orcid.org/0000-0001-9947-0261
local.identifier.orcidhttp://orcid.org/0000-0002-2050-0729
local.identifier.orcidhttp://orcid.org/0000-0002-5759-612X
local.identifier.orcidhttp://orcid.org/0000-0003-1383-6299
local.identifier.orcidhttp://orcid.org/0000-0001-5605-6976
local.identifier.orcidhttp://orcid.org/0000-0001-7643-6589
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jaos/a/sT8WBdmtYJBNt46DpwgXhSK

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