30 years of experience with non-hodgkin lymphoma in children and adolescents: a retrospective cohort study

Página do item simplificado
dc.creatorMaria Christina L.oliveira
dc.creatorKeyla Christy Christine Mendes Sampaio Cunha
dc.creatorAndrea c. Brito
dc.creatorMarcia k. Campos
dc.creatorMitiko Murao
dc.creatorRebeca Gusmão
dc.creatorAna Angélica l. Fernandes
dc.creatorMarcos b. Viana
dc.date.accessioned2023-05-11T20:16:09Z
dc.date.accessioned2025-09-09T01:07:05Z
dc.date.available2023-05-11T20:16:09Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1590/1806-9282.66.1.25
dc.identifier.issn18069282
dc.identifier.urihttps://hdl.handle.net/1843/53129
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.rightsAcesso Aberto
dc.subjectLinfoma não Hodgkin
dc.subjectCriança
dc.subjectEstudos de Coortes
dc.subject.otherLymphoma Non-Hodgkin
dc.subject.otherChild
dc.subject.otherCohort Studies
dc.title30 years of experience with non-hodgkin lymphoma in children and adolescents: a retrospective cohort study
dc.typeArtigo de periódico
local.citation.epage30
local.citation.issue1
local.citation.spage25
local.citation.volume66
local.description.resumoOBJECTIVE: Describe the clinical and demographic characteristics of pediatric patients with non-Hodgkin’s lymphoma (NHL) enrolled in a tertiary unit of Pediatric Hematology between 1982-2015. PATIENTS AND METHODS: A retrospective cohort study of 140 patients aged 16 years or less with NHL. Demographic characteristics, data on diagnosis, and outcomes were analyzed. The overall survival (OS) analysis and stratification by the most frequent histological subtypes were performed using the Kaplan-Meier method. RESULTS: One hundred and thirty-six patients with de novo NHL and four with NHL as a second malignancy were analyzed. The median age at diagnosis was 6.4 years (interquartile range, 4.2 to 11.1 years); 101 patients were males. Four patients had primary immunodeficiency, four had human immunodeficiency virus, two post-liver transplantation, and one had autoimmune lymphoproliferative syndrome. The most frequent histological type was NHL of mature B- cell (B-NHL-B; 67.1%), with Burkitt’s lymphoma being the most frequent subtype, and lymphoblastic lymphoma (LBL, 21.4%). The main clinical manifestation at the diagnosis was abdominal tumors (41.4%). During the follow-up time, 13 patients relapsed, but five of them reached a second remission. Thirty-five patients died, and 103 remained alive in clinical remission. No contact was possible for two patients. The OS at 5 years was 74.5% (± 3.8%). The OS estimated for patients with LBL, NHL-B, and the remaining was 80.4%±7.9%, 72.8%±4.7%, and 74.5%±11%, respectively (P = 0.58).
local.identifier.orcidhttps://orcid.org/0000-0002-4049-4645
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/ramb/a/CyvkJjNvNywCL4M3dyqhwMx/?lang=en

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
30 years of experience with Non-Hodgkin Lymphona in Children and Adolescents a retrospective cohort study.pdf
Tamanho:
149.71 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG