The antineoplastic potential of crotoxin isolated from Crotalus durissus terrificus snake venom on oral squamous cell carcinoma

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dc.creatorRogério Gonçalves da Rocha
dc.creatorEliane Macedo Sobrinho Santos
dc.creatorAnita Mitico Tanaka Azevedo
dc.creatorCaroline Serino Silva
dc.creatorMarcela Gonçalves de Souza
dc.creatorEmisael Stênio Batista Gomes
dc.creatorFelipe Alberto Dantas Guimarães
dc.creatorLuiz Henrique Silveira
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorRicardo Santiago Gomez
dc.creatorAndré Luiz Sena Guimarães
dc.creatorLucyana Conceição Farias
dc.date.accessioned2024-10-09T21:16:43Z
dc.date.accessioned2025-09-09T00:13:17Z
dc.date.available2024-10-09T21:16:43Z
dc.date.issued2023-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.toxicon.2022.106965
dc.identifier.issn1879-3150
dc.identifier.urihttps://hdl.handle.net/1843/77349
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofToxicon
dc.rightsAcesso Aberto
dc.subjectBoca - Câncer
dc.subjectCarcinoma de células escamosas
dc.subjectCrotoxina
dc.subjectCobras venenosas - Veneno
dc.subject.othercarcinoma de células escamosas de boca
dc.subject.othercâncer de cabeça e pescoço
dc.subject.otherTRATAMENTO
dc.titleThe antineoplastic potential of crotoxin isolated from Crotalus durissus terrificus snake venom on oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.spage106965
local.citation.volume221
local.description.resumoThis study investigated the antineoplastic effects of crotoxin isolated from snake venom of the South American Crotalus durissus terrificus in oral cancer cell lines and in an animal model of chemically induced oral cancer. We analyzed cell viability and death, clonogenic formation, DNA fragmentation, migration assay, and gene expression of MMP2, MMP9, COL1A1, and CASP3. In the animal model, after induction of oral cancer by 4-nitroquinoline-1-oxide carcinogen, mice were treated with crotoxin to investigate its effects on tumor development in tongue and oral mucosa. Crotoxin inhibited cell proliferation, viability, colony formation, and migration, favoring cell death. Furthermore, crotoxin increased caspase-3 expression, decreased Ki-67 protein and mRNA expression of MMP2, MMP9, and COL1A1. Mice treated with crotoxin at 10 μg/kg did not alter biochemical parameters total cholesterol, very-low-density lipoprotein, high-density lipoprotein, liver transaminases, glycemia, creatinine, and urea. Crotoxin treatment significantly reduced the frequency of oral squamous cell carcinoma lesions by 50%. Thus, this study highlights crotoxin as a promising chemotherapeutic substance, considering its effects on controlling the neoplastic cell population, reducing cell migration, and inhibiting tumor development. Clinical studies are necessary to understand better the impact of crotoxin as a potential adjuvant therapeutic agent for oral cancer patients.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0041010122003166?via%3Dihub

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