Ocular inflammatory events following COVID-19 vaccination: a multinational case series

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dc.creatorIlaria Testi
dc.creatorCarl Herbort
dc.creatorLuca Cimino
dc.creatorSalam Iriqat
dc.creatorJennifer e. Thorne
dc.creatorJose Echegaray
dc.creatorKalpana Babu
dc.creatorAlexander Arthur Bialasiewicz
dc.creatorDebra a. Goldstein
dc.creatorNima Ghadiri
dc.creatorAlex Fonollosa Calduch
dc.creatorCamilo Brandão-de-resende
dc.creatorGabriel Costa de Andrade
dc.creatorPadmamalini Mahendradas
dc.creatorJulio j. González-lópez
dc.creatorEster Carreño
dc.creatorRola n. Hamam
dc.creatorNicole Stübiger
dc.creatorBahram Bodaghi
dc.creatorYu-jang Chao
dc.creatorMasaru Takeuchi
dc.creatorMei-ling Tay-kearney
dc.creatorRupesh Agrawal
dc.creatorAlejandro Portero
dc.creatorHiroshi Keino
dc.creatorMar Esteban-ortega
dc.creatorJoanna Prze'dziecka-do'yk
dc.creatorAleksandra Radosavljevi'
dc.creatorIan Paredes
dc.creatorho su Ling
dc.creatorWei Kiong
dc.creatorMelissa Tien
dc.creatorCarlos Pavesio
dc.creatorXin le ng
dc.creatorSoon Phaik Chee
dc.creatorJay Siak
dc.creatorInes Hernanz-rodriguez
dc.creatorVictor Menezo
dc.creatorChristoph Tappeiner
dc.creatorFranz Marie Cruz
dc.creatorPeter Addison
dc.creatorLaura Steeples
dc.creatorRobert Kuijpers
dc.creatorDaniel Vítor de Vasconcelos Santos
dc.creatorBalini Balasubramaniam
dc.creatorPeter Mccluskey
dc.creatorFrancesco Pichi
dc.creatorAniruddha Agarwal
dc.date.accessioned2023-12-06T19:27:15Z
dc.date.accessioned2025-09-08T23:18:25Z
dc.date.available2023-12-06T19:27:15Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s12348-021-00275-x
dc.identifier.issn1869-5760
dc.identifier.urihttps://hdl.handle.net/1843/61800
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Ophthalmic Inflammation and Infection
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectVacinação
dc.subjectSARS-CoV-2
dc.subjectInflamação
dc.subjectUveíte
dc.subject.otherUveitis
dc.subject.otherOcular inflammation
dc.subject.otherImmunomodulatory
dc.subject.otherCoronavirus disease
dc.subject.otherCOVID-19
dc.subject.otherSARS-CoV-2
dc.subject.otherVaccination
dc.titleOcular inflammatory events following COVID-19 vaccination: a multinational case series
dc.typeArtigo de periódico
local.citation.epage6
local.citation.issue4
local.citation.spage1
local.citation.volume12
local.description.resumoBackground Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions. Methods Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021. Results Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19–84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1–14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%). Conclusion Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome.
local.identifier.orcidhttps://orcid.org/0000-0002-6747-2024
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://joii-journal.springeropen.com/articles/10.1186/s12348-021-00275-x

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