Synthesis of dihydropyrazoles via Pd-catalyzed heterocyclization/carbonylation reaction: development and parameterization studies

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Tipo

Artigo de periódico

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Primeiro orientador

Membros da banca

Resumo

A Pd-catalyzed heterocyclization/carbonylation cascade reaction encompassing the formation of 3 new bonds, affording dihydropyrazole-esters in moderate to excellent yields and good functional group tolerance is described, comprising a new methodology for direct access to esterified heterocycles using alcohols as readily available feedstock. Optimization was carried out along with a phosphine/base parameterization study, providing important structure-reactivity insights for pyridine-bases, mono- and bisphosphines.

Abstract

Assunto

Catálise, Reações quimicas, Formação de aneis (Quimica), Compostos heterociclicos, Fosfina, Piridina

Palavras-chave

Palladium catalysis, Heterocyclization, Carbonylation, Parameterization studies, Cascade cyclization

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Curso

Endereço externo

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202200894

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