Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin

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dc.creatorLubia Guaima Nascimento
dc.creatorSuellen Aliani Lopes
dc.creatorAyron Breno Lima Teodolino
dc.creatorKátia Monteiro Novack
dc.creatorAna Paula Moreira Barboza
dc.creatorBernardo Ruegger Almeida Neves
dc.creatorMaria Luíza Schaefer Azevedo
dc.creatorLucas Resende Dutra Sousa
dc.creatorViviane Martins Rebello dos Santos
dc.date.accessioned2023-07-10T19:31:40Z
dc.date.accessioned2025-09-08T23:53:45Z
dc.date.available2023-07-10T19:31:40Z
dc.date.issued2020
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.21577/0100-4042.20170537
dc.identifier.issn1678-7064
dc.identifier.urihttps://hdl.handle.net/1843/56037
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuímica Nova
dc.rightsAcesso Aberto
dc.subjectPolímeros
dc.subject.otherPolyethyleneglycol
dc.subject.otherIndomethacin
dc.subject.otherControlled release
dc.titleNovel PEG 4000 derivatives and its use in controlled release of drug indomethacin
dc.typeArtigo de periódico
local.citation.epage691
local.citation.issue6
local.citation.spage685
local.citation.volume43
local.description.resumoThe insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded as drug-modulating controllers at specific sites in the body. Indomethacin has been used in the controlled release of drugs because it is a drug that have good interaction with different polymers. The drug is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, osteoarthritis, spondylitis, and other disorders. In this work, PEG 4000 had its chain modified by organic reactions and their derivatives were emulsified to form microparticles using polyvinyl alcohol as an emulsifier. Posteriorly were also incorporated with indomethacin. The samples were characterized to prove the influence of indomethacin on the morphology and thermal behavior of this polymer. The controlled release was performed in the time from 0 to 240 min using the Ultraviolet Spectroscopy to quantify indomethacin released from the polymer matrix for these 4 hours. Releases over the time were satisfactory as concentrations increased over time, which we can conclude that the structural modification of PEG 4000 was beneficial in the release of the indomethacin drug.
local.identifier.orcidhttps://orcid.org/0000-0003-2451-3436
local.identifier.orcidhttps://orcid.org/0000-0002-0644-9197
local.identifier.orcidhttps://orcid.org/0000-0002-1807-971X
local.identifier.orcidhttps://orcid.org/0000-0003-0464-4754
local.identifier.orcidhttps://orcid.org/0000-0003-2408-3448
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://quimicanova.sbq.org.br/detalhe_artigo.asp?id=9089

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